By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on Gastroenterology - Colorectal Research. According to news reporting originating in Hubei, People’s Republic of China, by NewsRx journalists, research stated, “Multiple single nucleotide polymorphisms (SNPs) have been found to be highly correlated with colorectal cancer (CRC) risk. However, the variants identified thus far only explain a small part of the cases, suggesting the existence of many uncharacterised genetic determinants.”
The news reporters obtained a quote from the research from the Huazhong University of Science and Technology, “In this study, using the multilevel ‘omics’ data provided in The Cancer Genome Atlas, we systematically performed expression quantitative trait locus (eQTL) analysis for CRC and identified nine SNPs with significant effects on mRNA expression (correlation vertical bar r vertical bar > 0.3 and FDR < 0.01). Then we conducted a two-stage case-control study consisting of 1528 cases and 1528 controls to examine the associations between candidate SNPs and CRC risk. We found that rs27437 in SLC22A5 was significantly correlated with CRC risk in both stages and the combined study (additive model, OR = 1.31, 95%CI = 1.17-1.47, P = 1.97 x 10(-6)). eQTL analysis showed that rs27437 GG and GA genotypes were associated with lower expression of SLC22A5 compared with the AA genotype. Dual-luciferase reporter assays confirmed that the G risk allele could decrease the expression of luciferase.”
According to the news reporters, the research concluded: “SLC22A5 was significantly decreased in CRC tumour tissues compared with adjacent normal tissues, indicating that SLC22A5 may play important roles in CRC, and rs27437 in SLC22A5 might serve as a novel biomarker for early detection and prevention of CRC.”
For more information on this research see: Integrative expression quantitative trait locus-based analysis of colorectal cancer identified a functional polymorphism regulating SLC22A5 expression. European Journal of Cancer , 2018;93():1-9. European Journal of Cancer can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; European Journal of Cancer - http://www.journals.elsevier.com/european-journal-of-cancer/)
Our news correspondents report that additional information may be obtained by contacting J. Gong, Huazhong University of Science & Technology, State Key Lab Environm Hlth Incubat, Key Lab Environm & Hlth WuhanSch Public HlthTon, MOE Minist EducKey Lab Environm & HlthDept Epid, Wuhan, Hubei, People’s Republic of China. Additional authors for this research include J. Lou, J.T. Ke, S.F. Mei, J.Y. Li, Y.J. Gong, Y. Yang, Y. Zhu, J.B. Tian, J. Chang, R. Zhong, D.Y. Zou and X.P. Miao.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2018, NewsRx LLC
CITATION: (2018-04-24), Reports from Huazhong University of Science and Technology Provide New Insights into Colorectal Research (Integrative expression quantitative trait locus-based analysis of colorectal cancer identified a functional polymorphism regulating ...), Cancer Weekly, 531, ISSN: 1532-4567, BUTTER® ID: 015535782
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