Autophagy and Fasting-A great podcast by Mike Mutzel of High Intensity Health

A great in depth examination of fasting and autophagy by Mike Mutzel. Mike and his H.I.H. podcasts are a great source of up to date research on nutrition and it's effects on our health. If you're interested in learning a lot about nutrition and the latest work by a multiple of researchers out there then please check out his blog and videos on his High Intensity Channel. Straight up great info and not all of the B.S. and drama of the vegan vs keto/carnivore diets that seems to be all too prevalent (at least to me).

JULY 11, 2019
Autophagy & Fasting Deep Dive – High Intensity Health

Check out the High Intensity Health blog

This podcast, hosted by Mike Mutzel, is a deep dive into all things autophagy

Key Takeaways
Autophagy is the process by which cells (or cellular components) eat themselves under conditions of nutrient deprivation (AKA fasting)
The dysfunctional cells (like cancer cells) or dysfunctional cell components tend to be “eaten” first
Autophagy is tissue specific – it’s not an on/off phenomenon
There’s probably some basal or static levels of autophagy occurring in pretty much every tissue of the body in most individuals (most of the time)
Exercise is one of the best ways to enhance autophagy – how so?
Research dictates that in skeletal muscle, autophagy related proteins are present in higher amounts after 12, 24, and 36 hours of fasting in lean/trained people compared to overweight individuals
(In simple terms – this indicates people who exercise frequently may start undergoing autophagy in a shorter amount of time during a prolonged fast)
Research seems to indicate the more insulin sensitive you are the more readily you can enhance autophagy
How long do you need to fast in order to increase autophagy significantly?
Probably 72 hours (but if you exercise frequently, perhaps this number drops to ~36 hours)
And the link to the podcast and write-up.
https://podcastnotes.org/2019/07/11/autophagy/