The 13 remaining top-tier clubs made an average of 5.8 changes to their line-ups and only five made sure of their places in the fifth round.
Nine of the teams replaced at least half of their line-ups from their last league fixture but only three of them won, with two of those victories gained against fellow top-tier sides who had also made plenty of changes.
Watford altered their entire team for the second-straight round but they eased to victory over Newcastle, who made seven alterations to their starting line-up.
Tottenham made seven changes from their league win over Fulham but lost 2-0 to a Crystal Palace side showing six alterations.
Burnley rotated seven players, but were thrashed 5-0 by a Manchester City side that replaced just four starters from their league fixture with Huddersfield.
Brighton, West Ham and Wolves all failed to win against lower-league opposition after making six changes.
Manchester United made five changes to Arsenal's three for their heavyweight clash, but Ole Gunnar Solskjaer's team earned a 3-1 away win.
Which team did you support? What results were you expecting?
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