1918: Early work with Guanidine (Synthlin use stopped In early 1920s) .
1922: First Exogenous Insulin administered to a Human.
1959: Metformin Introduced.
1983: First Recombinant Human Insulin.
1984: Second generation SUs.
2006: First DPP-4 inhibitor (Sitagliptin, Linagliptin).
2008: Colesevelam approved for Diabetes.
2009: Bromocriptine approved for Diabetes.
2013: First SGLT-2 inhibitor (Dapagliflozin). 
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