Insulin resistance syndrome, now known as metabolic syndrome (MS) is a highly prevalent clinical condition in Chile. Because of the high associated risk of this condition with cardiovascular disease and type 2 diabetes, in the clinical practice is relevant its early detection and management. Insulin resistance (IR) is a key metabolic condition in the pathogenesis of MS, and its diagnosis can be made with fasting plasma glucose and insulin measurements or by an oral glucose tolerance test with insulin curve. There is agreement that the best results of the management of MS and insulin resistance are achieved with lifestyle modifications, including changes in diet and physical activity patterns along with weight reduction and body fat. Some pharmacological therapies targeted on improving insulin sensitivity, have been recommended in international consensus, especially in patients at high risk of cardiovascular disease or type 2 diabetes, when nonpharmacological strategies have failed.
Insulin resistance syndrome, now known as metabolic syndrome (MS) is a highly prevalent clinical condition in Chile. Because of the high associated risk of this condition with cardiovascular disease and type 2 diabetes, in the clinical practice is relevant its early detection and management. Insulin resistance (IR) is a key metabolic condition in the pathogenesis of MS, and its diagnosis can be made with fasting plasma glucose and insulin measurements or by an oral glucose tolerance test with insulin curve. There is agreement that the best results of the management of MS and insulin resistance are achieved with lifestyle modifications, including changes in diet and physical activity patterns along with weight reduction and body fat. Some pharmacological therapies targeted on improving insulin sensitivity, have been recommended in international consensus, especially in patients at high risk of cardiovascular disease or type 2 diabetes, when nonpharmacological strategies have failed.
https://www.sciencedirect.com/science/article/pii/S071686401370230X