"The research, identifying how the virus attacks the body, can have implications on the development of anti-viral drugs for Covid-19."
https://www.outlookindia.com/website/story/world-news-compounds-that-inhibit-entry-replication-of-coronavirus-in-human-cells-identified-study/363875
"A virus particle consists of only a genome, a protein coat or capsid, and sometimes a surrounding lipid envelope. To replicate, a virus must successfully enter a host cell, uncoat its genome, and appropriate the host cell machinery to replicate its genome and produce viral proteins."
https://www.ibiology.org/cell-biology/viral-infection/
"Viruses must first penetrate and enter the cell before viral replication can occur. From the perspective of the virus, the purpose of viral replication is to allow reproduction and survival of its kind."
https://courses.lumenlearning.com/boundless-microbiology/chapter/viral-replication/
"significant efforts have been made in discovering peptides and small molecules that inhibit the fusion between virus and host cell, thereby inhibiting the entry of viruses."
https://link.springer.com/article/10.1007/s00232-020-00136-z
"An antiviral agent must act at one of five basic steps in the viral replication cycle in order to inhibit the virus: (1) attachment and penetration of the virus into the host cell, (2) uncoating of virus (e.g., removal of the protein surface and release of the viral DNA or RNA), (3) synthesis of new viral components by the host cell as directed by the virus DNA, (4) assembly of the components into new virus, and (5) release of the virus from the host cell."
https://www.britannica.com/science/antiviral-drug
"If we can develop compounds to shut down or significantly reduce both processes - viral entry and viral replication - such dual inhibition may enhance the potency of these compounds in treating the coronavirus infection," said study co-principal investigator Yu Chen, PhD, a USF Health associate professor of molecular medicine with expertise in structure-based drug design. "Metaphorically, it's like killing two birds with one stone."
https://www.eurekalert.org/pub_releases/2020-11/uosf-srs110620.php
"RNA viruses, including poliovirus, respiratory syncytial virus, picornaviruses, influenza virus, and coronavirus can all be stopped at the cellular level by increasing the intracellular concentration of zinc. Medical researchers from the Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, in the Netherlands explain that the replication of all these viruses can be stopped when zinc concentrations force a correction of proteolytic processing of viral polyproteins."
https://www.naturalmedicine.news/2020-06-10-zinc-effective-treatment-for-coronavirus-infection-blocks-viral-replication.html
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