EG.5 remains the most prevalent variant in the US. This list looks intimidating, but most of these variants have identical or very similar spike proteins. Therefore the new coronavirus vaccines should protect against circulating variants.
BA.2.86 is still not prevalent enough to register on this. Still too early to know if it will outcompete the other variants. Early pseudovirus neutralization data suggests the new vaccines will protect against it. The CDC is distributing real virus isolates of it to labs, so hopefully we get more robust neutralization data this week.