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Bitfinex doesn't handle US based customers:
https://www.bitfinex.com/posts/227

Binance gave me issues at first is discontinued trying. Settled on a smaller more mainstream cryptos, BTC, ETH, LTC, BCH, and STEEM. Looked at XRP and DASH but opted to hols my LTC rather than trade it out.

Supposedly the new IXI module coming out soon will make it a lot easier for exchanges to add support for IOTA.