Patients will be given key ingredient from magic mushrooms in new trial to beat depression

By Phoebe Southworth For Mailonline

The hallucinogenic powers of the psychedelic mushrooms are well known, but now they could be used to combat particularly severe forms of the condition.

British start-up Compass Pathways is poised to put this theory to the test with hundreds of patients who have untreatable depression.

It will hold a 400-patient trial aims to find out if psilocybin, the active ingredient in magic mushrooms, can help them.

A third of the 300million depression patients worldwide have a condition which is resistant to existing treatment.

In a study involving 20 patients last year, researchers at Imperial College London found that sufferers described a sense of their brains 'rebooting' after just two psilocybin experiences.

The 400-patient trial aims to see if psilocybin, the active ingredient in magic mushrooms (pictured right) could be a breakthrough treatment for the condition

Ekaterina Malievskaia, co-founder and chief medical officer of the London-based start-up, started the business with her husband George Goldsmith.

They wanted to find a new way of treating depression after seeing a close family member suffer from the condition.

She told The Sunday Times: 'Based on previous trials, psilocybin provides an immediate and sustained relief from depression, instils a sense of wellbeing, and improves quality of life.'

Mr Goldsmith added: 'We need a new approach to tackling mental health.

'There is still a significant unmet need for a large number of patients living with this very challenging condition.'

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