Unusual blood clots in the brain have been detected in a handful of people after they were injected with the Oxford-AstraZeneca vaccine.
These "cerebral venous sinus thromboses" or CVSTs have led some countries - including Germany, France and Canada - to restrict who can be given the jab. The World Health Organization and the European Medicines Agency say the benefits of the vaccine outweigh any risks.
Scientists and medicines safety regulators around the world are trying to figure out if the vaccine is genuinely causing these strokes, how big any risk might be and what that might mean for vaccination programmes.
Is the vaccine causing clots?
At the moment, we do not know.
The European Medicines Agency (EMA), which has been reviewing the safety data, says it is "not proven, but is possible".
The organisation has to figure out whether the reported clots are a side-effect or a coincidence that would have happened naturally. This is incredibly hard when dealing with rare events. If, on the other hand, one in every 10,000 people was having serious blood clots then the answer would be obvious.
I have spoken to respected scientists some of whom are sceptical, others increasingly convinced.
Some point to the highly unusual nature of the clots as a sign something could be going on. They are often appearing at the same time as low levels of blood platelets, which are one of the main components of a clot, and antibodies linked to other clotting disorders appearing in the blood.
Others say there is not enough proof and the reported cases could plausibly be down to Covid, which itself is linked to abnormal clotting.
How big might the risk be?
It remains entirely possible the risk is zero as vaccines are not proven to cause the brain clots.
Germany's Paul Ehrlich Institute has reported 31 cerebral venous sinus thromboses and nine deaths out of 2.7 million people vaccinated there
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