In the first leg of this quarterfinal match at Old Trafford, Manchester United will face Sevilla, another opponent from Spain.
Erik ten Hag, the coach of the Red Devils, must defeat the Los Nervionenses, the record six-time champions of this competition, after earlier victories against Real Betis and Barcelona.
The seasoned José Luis Mendilibar is now in command of Sevilla after the recent dismissal of Coach Jorge Sampaoli. Sevilla has struggled at home this season and is currently in the bottom half of La Liga.
Marcus Rashford, who has scored 28 goals this season, is out with a groin injury, which has dealt United a major injury blow ahead of this crucial match.