This article explains the relationship between hypertension, renal function and obesity. It pays particular attention to the pressure-natriuresis mechanism and its impairment in obesity, through activations of the sympathetic nervous system and of the renin-angiotensin system.
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Leptin seems to be related to sympathetic nervous system activation at the level of the kidneys.
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In addition to that obesity seems to activate the renin angiotensin system.
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