Increased Metabolic Production of Oxalate.
Oxalate is produced as a metabolic product of vitamin C (ascorbic acid). About 10 mg per day are produced through this pathway, representing the majority of the endogenous oxalate production. This means that about 33% of the excreted oxalate results from the metabolism of ascorbic acid, taking into account that the average oxalate excretion is about 30 mg/day. People who take vitamin C supplements excrete more oxalates and form more kidney stones that people who do not.
The metabolism of hydroxyproline, glycine and glyoxal also generates oxalate. The metabolism of all these compounds accounts for 25% of all the excreted oxalate (average 7.5 mg). Hydroxyproline sources are mainly all types of meat.
Bibliography
Taylor, Eric, Meir Stampfer, Gary Curhan. “Dietary factors and the risk of incident kidney stones in men: new insights after 14 years of follow-up.” Journal of the American Society of Nephrology 15, no. 12 (2004): 3225-3232. doi: https://doi.org/10.1097/01.ASN.0000146012.44570.20.
Levine, Mark, Cathy Conry-Cantilena, Yaohui Wand, Richard W. Welch, Philip W. Washko, Kuldeep R. Dhariwal, Jae B. Park, Alexander Lazarev, James F. Graumlich, Jean Kings, and Louis R. Cantilena. “Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance.” Proceedings of the National Academy of Sciences 93, no. 8 (1996): 3704-3709. doi: 10.1073/pnas.93.8.3704.
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Ramos, Marco.“Calcium Oxalate Kidney Stones For Everyone. #2C. What Causes Calcium Oxalate Kidney Stones?”. SMO Blog (blog). Second Medical Opinions PLC, February 18, 2020. https://steemit.com/hive-163521/@secondmedicalop/calcium-oxalate-kidney-stones-for-everyone-2c-what-causes-calcium-oxalate-kidney-stones
Read the other sections of this series:
Introduction
What Causes Calcium Oxalate Kidney Stones? A
What Causes Calcium Oxalate Kidney Stones? B