Hypothyroidism – the quiet plague

Dealing with goitrogens, autoimmunity, and other thyroid disrupters

One of the first things fermentation guru Sandor Katz and I discussed when we met was the issue of goitrogenic foods in ferments. Unless you’ve been living under a rock you will have heard of the many benefits to be derived from eating fermented foods, but the idea that the cruciferous vegetables that dominate a lot of ferments contain substances that can potentially inhibit thyroid function may be new to you. The good news is that by taking care of our thyroid with the relatively simple measures outlined here, we can continue to reap the many health benefits of fermented foods.

There has been a huge rise in hypothyroidism in recent times. Current data indicates that 12% of the population will experience some form of thyroid disorder in their lives, and this number is quietly, but steadily increasing. It is estimated that up to 90% of hypothyroidism in areas with sufficient dietary iodine has an autoimmune basis. Analysis of the year to year increase in hypothyroid conditions indicates that extrinsic or environmental factors must be the prime driving mechanism. Women are most widely affected, but the handful of studies that have quantified the rise of hypothyroidism indicate that the relative percentages of both men and young people are on the increase.

Conventional medical treatment for hypothyroidism involves either supplementation with synthetic or biologically similar thyroid hormones, or with iodine, but obviously this achieves nothing in a healing context where the causal mechanism is auto-immunity driven by external factors. As is often the case, we address the symptoms, not the cause, and if we are lucky, we will receive some dietary advice which may or may not be helpful.

Much attention has been directed by dieticians, scientists and physicians to the so called goitrogenic foods – cruciferous vegetables. Goitrogens are foods that inhibit bodily uptake of iodine, or that inhibit the utilisation of iodine by the thyroid gland, and so are implicated in hypothyroidism, related goitre formation, and thyroid cancer. Goitrogens also inhibit the transfer of iodine to breast milk. At the same time, these foods are widely touted by dieticians, scientists and physicians as having anti-inflammatory, anti-cancer, anti-oxidant, and detoxifying properties, and strangely enough, both the pro and con arguments for cruciferous vegetables revolve around the same group of compounds – the glucosinolates.

The different forms of glucosinolates in crucifers are broken down in the body to three groups of compounds: isothiocyanates, indoles, and nitriles. All three groups have been studied for either potent anti-carcinogenic, detoxification, anti-viral, or anti-bacterial properties. All three groups have also been identified as potentially harmful, with effects such as inhibition of thyroid hormone production, and tissue-based cyanide toxicity having been experimentally demonstrated. A word of caution here: many experiments are conducted at higher doses than would be found in food, on isolated compounds only (so not as found in nature), and obviously, rarely on humans. Regardless of this caveat, we tend to base our choices on what these kinds of experiments show us, and when there is conflicting advice, we can be understandably confused.

First, we should understand that glucosinolates are a part of the crucifer defence mechanism against herbivory. They are inert substances until activated by the accompanying enzyme myrosinase. In the plant tissue, glucosinolates and myrosinase are segregated, but the action of chewing breaks down the compartment walls, and the formation of what is fundamentally a range of irritant and toxic chemicals is initiated. In humans, high doses of these toxins are required to initiate substantial effects. For example, isothiocyanates are metabolised in the body into two functional groups: thiocyanate ions and thioureas, with the former being produced in much larger numbers. Thiocyanate ions inhibit uptake of iodine by the thyroid gland, but this can be ameliorated by a sufficiency of iodine in the diet. Thioureas, however, shut down the enzyme that allows iodine to be used in the manufacture of thyroid hormones. In a nut shell, dietary iodine can allow the body to cope with low levels of isothiocyantes, but not high levels. The effects of iodine deficiency are exacerbated by a bodily lack of vitamins A and E, selenium, zinc and iron. This indicates that while crucifers confer health benefits, we should eat them sparingly if we have concerns about our thyroid, and ensure we have adequate dietary iodine, selenium, zinc, iron, and vitamins A and E. In other words, we could say treat crucifers as a medicine food that fits into a well balanced diet, one in which they are not eaten in too great a quantity.

Reduction in thyroid function may result from many factors, and these often occur in concert, and on a regular basis. Habitual use of refined sugars and starches (particularly without fats or protein as balance) depletes the thyroid of hormones as these are part of the emergency blood sugar balancing response of the body; repeated exposure to endocrine disrupters that inhibit thyroid activity, the most common being fluoride in drinking water (fluoride therapy has been used to inhibit thyroid function in cases of hyperthyroidism); phytoestrogens (for example, from unfermented soy products); exposure to dioxins, PCBs, EBDCs and perchlorate; exposure to high levels of ionising radiation (includes mobile phone tower emissions, smart phones, cordless phones, wifi modems, and X-rays); stress (adrenal fatigue), and; input of hormones or their analogues through our diet or environment (for example, even food safe plastics will leach oestrogen-like compounds into our food). Even though endocrine disrupters work in concert, they are studied in isolation, so the combined effects of disrupters on thyroid function are most likely greatly in excess of any single effect reported in scientific literature. Disruption of thyroid function may be tied to overall hormonal imbalance, and it is worth noting that women are more likely to become hypothyroid immediately after childbirth, and after menopause. Avoidance of known external endocrine disrupters is therefore of particular importance to women, and hormonal means of birth control must be included in this consideration.

Stress deserves special consideration. Cortisol is the hormone we release in times of stress and low blood-glucose concentrations, and high levels of cortisol are associated with a factor of importance here: immune system suppression. There is a condition known as thyroid resistance, where the receptors to thyroid hormones that exist throughout our entire body are somehow shut down, and the primary cause of this is stress and high cortisol levels. Though thyroid resistance is not an auto-immune condition, high cortisol may also lead to auto-immunity to thyroid tissue by a rather circuitous route involving our immune cells confusing gliadin (the protein component of gluten) and thyroid tissue. Gliadin and thyroid tissue are very similar at the molecular level, and gluten entering the bloodstream through a compromised gut is tagged by the immune system as an invader. Unfortunately, an immune system suppressed and confused by wildly fluctuating cortisol levels all too easily attacks thyroid tissue along with the gliadin, because it is unable to tell the two apart. I would strongly recommend removing gluten from the diet completely if you have (or suspect you have) any thyroid or auto-immune condition, or a compromised gut and/or immune system.

Given that around 90% of hypothyroidism has an autoimmune basis, it stands to reason that eliminating substances that promote an exaggerated immune response within the body can be beneficial. Here, we are talking about things such as mercury, lead, aluminium, toluene, squalene (intravenously, not orally as found naturally occurring in many oils) and fluoride, many of which are used as adjuvants in vaccines precisely because an exaggerated immune response is crucial for the theory of vaccine efficacy. Hand in hand with this is the issue of chronic systemic inflammation and subsequent compromising of the immune system. Once our immune system is compromised, we increasingly lose the ability to differentiate between “me” and “other”, and so we begin to war with ourselves – healthy bodily tissues may be attacked by our immune cells as readily as pathogens and foreign bodies. Just how this translates into a recognised autoimmune condition depends on our diet, on the background state of our individual body and environment, and also on our genetic inheritance. Regardless of which autoimmune condition we present with, dealing with chronic inflammation is an essential first step on the road to health, along with steps such as dietary change, minimisation of exposure to toxic substances, and replenishment of our internal micro-biota of probiotic organisms.

Fermented foods often rely on cruciferous vegetables – traditionally, these are associated with substantial health benefits, and much scientific research has corroborated what our ancestors observed, or knew intuitively about them. The fermentation of food does not destroy goitrogens, cruciferous vegetables need to be well boiled for an extended period to reduce the goitrogen content by 90%. But then, fermented foods are only ever intended to be a condiment, and one addition to a well balanced diet. The inclusion of cruciferous vegetables to ferments creates powerful functional foods, and there is no reason not to ferment them as long as we maintain adequate dietary inputs of iodine, selenium, zinc, iron, and vitamins A and E, and avoid known thyroid and other endocrine disruptors. Here is a list of good thyroid foods, but remember, they must be organic to be most beneficial: kelp and other seaweeds (reliable high levels of all factors, the best source), unrefined sea salt, Himalayan salt, bone broths, dark green vegetables (though some report that spinach blocks iodine absorption), butter and other dairy (preferably raw, and from grass-fed, A2 protein animals), eggs, kefir-fermented milk and yogurt, oregano, strawberries, cranberries, artichokes, asparagus, and navy beans. Seafood is not included in this list because though oceanic fish can contain good levels of essential thyroid support nutrients, they are also a prime dietary source of mercury, which as we have seen, is to be avoided at all costs.

In closing, if you believe that hypothyroidism, goitrogenic foods, chronic inflammation, a compromised immune system, or endocrine disrupters may be an issue for you, consult a naturopath or a conventional doctor with a broad or holistic outlook. As well as relying on professional advice, the internet is an amazing resource (if used sensibly) that allows us to research virtually anything. This empowers us all to become our own health detectives, and to become an active participant in our own healing and well-being.

© Copyright Tom Rothsey. This content may be freely shared on social media, or linked to on any web platform, but all other use or reproduction requires authorisation from the author. Magic is the intelligence of love.

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Bio

Tom Rothsey is an ecologist, environmental scientist, reflexologist, energy worker, health and lifestyle coach, writer, researcher, and teacher of the fermented arts in all their forms. He lives with his wife Christy Lavers, and their son Jasper Blue in a pole house, in a rainforest in North Eastern New South Wales, Australia.

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Article originally posted on Wake Up World https://wakeup-world.com/2015/10/19/hypothyroidism-the-quiet-plague/