What's the true meaning of the passage? Obviously, Paul knows nothing about homosexuality or transgenderism as we understand those terms, though I'm sure he has a solid idea of the activity and ideas involved.

But Paul is (probably) referencing the creation account in Genesis 1 when he says "male and female" in Galatians 3. He changes the formula from "Jew OR Greek" and "slave OR free" to "male AND female," as in "male and female He created them."

Looks like Paul is denying something about the created order, something that normally separates male and female into a power structure or gives one preferential treatment (over the other). The seed for transgender politics is there, a reading of gender through the lens of the Christ in whom the created normativity is transcended.