Ashwagandha & Cancer

in medical •  3 years ago 

"Anticancer effect of Ashwagandha is generally attributable to steroidal lactones collectively referred to as withanolides. Withaferin A (WA) appears most active against cancer among structurally divergent withanolides isolated from the root or leaf of Ashwagandha."
https://curejoy.com/content/ashwagandha-for-cancer-treatment/

"Enhances the effects of chemotherapy and radiation against cancer cells23
Protects normal cells against damage from conventional cancer therapy4"
https://www.ashwagandha.com/modern-medical-uses/cancer

"studies showed that withanolides inhibit cyclooxygenase enzymes, lipid peroxidation, and proliferation of tumor cells."
https://pubmed.ncbi.nlm.nih.gov/16818501/

"A study from India’s Amravati University confirmed other recent research that a biochemical constituent of Ashwagandha (Withania somnifera) will inhibit the growth of cancer by interfering with the cancer cell’s ability to prevent destruction by the immune system."
https://plantmedicines.org/ashwagandha-inhibits-cancer-promotes-bone-healing-may-treat-parkinsons/?amp

"While most of the above research has been conducted using root extract, leaf extract also seems important. Leaf extract has been found to have at least seven components that can inhibit and attack cancer cells (15). Leaf extract was shown to be non-toxic in animal experiments.

Ashwagandha leaf extract was shown to have at least 5 anti-cancer pathways: p53 signalling. GM-CFS signalling, death receptor signalling, apoptosis signalling and G2-M DNA damage regulation pathway. The effects with p53 were the most pronounced."
https://www.canceractive.com/article/ashwagandha-reduces-cortisol-and-chronic-inflammation-in-the-body

"Numerous studies have highlighted impressive anti-cancer powers in ashwagandha:

A study in India found that ashwagandha could fight skin cancer by boosting the body’s production of its own antioxidants.3
Research on stomach cancer showed that ashwagandha could inhibit cancer growth possibly by stimulating the production of detoxifying enzymes in the liver.4
Investigations at the University of Kansas demonstrate that ashwagandha can slow the growth of ovarian cancer cells and increase their rate of apoptosis (programmed self-destruction).5"

https://www.cancerdefeated.com/if-you-feel-you-must-do-chemotherapyplease-add-this-herb/

"Lab studies indicate that ashwagandha’s anti-inflammatory effects have a regulating influence on the cell cycle, reducing angiogenesis or the proliferation of blood vessels around tumors. This can inhibit the spread and growth of cancer cells.
Additionally, an ashwagandha compound called withaferin can induce apoptosis or the death of cancer cells."
https://drvaidyas.com/10-amazing-health-benefits-of-ashwagandha/

Withania somnifera: from prevention to treatment of cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899165/

Selective Killing of Cancer Cells by Leaf Extract of Ashwagandha: Identification of a Tumor-Inhibitory Factor and the First Molecular Insights to Its Effect
https://clincancerres.aacrjournals.org/content/13/7/2298

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