Curcumin = Antiviral?

"Curcumin is the primary bioactive substance in turmeric, and has anti-inflammatory properties and decent evidence for indications from chronic pain to depression. It has poor bioavailability alone, necessitating special formulations to be efficiently absorbed."
https://examine.com/supplements/curcumin/

Natural Compound in Black Pepper Increases Curcumin Absorption Up to 2000%
https://dailyhealthpost.com/piperine-black-pepper-increases-bioavailability-nutrients/

"The good news is that black pepper isn’t the only compound that can help absorb more turmeric. New studies have introduced a fresh way of increasing curcumin’s bioavailability even further: pairing it with fat."
https://www.mygenefood.com/blog/curcumin-supplements-bioavailable-formula/

"The first suggestion that curcumin had antiviral properties came in the 1990s with the discovery that curcumin could inhibit the human immunodeficiency virus (HIV) viral protease in vitro, with a median inhibitory concentration (IC50) of 100 µM [31]. Since then, numerous studies have reported on the antiviral properties of curcumin against a diverse set of viruses, including those with RNA and DNA genomes, both enveloped and non-enveloped, as discussed in greater detail below."
https://www.mdpi.com/1999-4915/12/11/1242/htm

"It is reported that, curcumin exerts antiviral activities against broad spectrum of viruses including HIV, HSV-2, HPV viruses, Influenza virus, Zikavirus, Hepatitis virus and Adenovirus"
https://link.springer.com/article/10.1007/s12291-020-00902-9

"Research have additionally proven curcumin has an inhibitory impact on virus-induced cytokine storms, which happen on account of an overproduction of immune cells and pro-inflammatory cytokines."
https://www.editorials360.com/2020/07/06/curcumin-inhibits-virus-induced-cytokine-storm/

"Curcumin has been shown to inhibit the replication of some types of virus, including dengue virus, hepatitis B and Zika virus."
https://www.news-medical.net/news/20200717/Study-reveals-antiviral-effects-of-curcumin.aspx

"It has been shown that curcumin treatment can modify the structure of the surface protein in viruses, thereby blocking entry of virus and virus budding"
https://onlinelibrary.wiley.com/doi/full/10.1002/ptr.6738

"Previously, we reported that curcumin abrogated influenza virus infectivity by inhibiting hemagglutination (HA) activity. This study demonstrates a novel mechanism by which curcumin inhibits the infectivity of enveloped viruses. In all analyzed enveloped viruses, including the influenza virus, curcumin inhibited plaque formation. In contrast, the nonenveloped enterovirus 71 remained unaffected by curcumin treatment"
https://pubmed.ncbi.nlm.nih.gov/23658730/

"The results showed that curcumin could directly inactivate IAV, blocked IAV adsorption and inhibited IAV proliferation"
https://pubmed.ncbi.nlm.nih.gov/29153953/

"The research suggests that curcumin affects TGEV in a number of ways: by directly killing the virus before it is able to infect the cell, by integrating with the viral envelope to 'inactivate' the virus, and by altering the metabolism of cells to prevent viral entry."
https://www.sciencedaily.com/releases/2020/07/200717120154.htm

"This study demonstrates a novel mechanism by which curcumin inhibits the infectivity of enveloped viruses. In all analyzed enveloped viruses, including the influenza virus, curcumin inhibited plaque formation."
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062482

"Accumulated evidence indicated curcumin plays an inhibitory role against infection of numerous viruses. These mechanisms involve either a direct interference of viral replication machinery or suppression of cellular sig-naling pathways essential for viral replication, such as PI3K/Akt, NF-κB."
https://www.researchgate.net/publication/322069930_Antiviral_potential_of_curcumin

How Turmeric Fights These 7 Serious Viral Infections
https://www.turmericforhealth.com/turmeric-benefits/how-turmeric-fights-these-7-serious-viral-infections