Glycyrrhizin (Licorice Root) = Antiviral?

"Glycyrrhizin, an active compound found in licorice root, may possess powerful virus-fighting properties. An in vitro study in Lancet examined the anti-viral properties of several compounds and found that glycyrrhizin was the most effective at blocking the replication of SARS.

Another in vitro study had similar findings, noting that glycyrrhizin also exhibited cytotoxicity against the SARS virus."
https://www.healthy-holistic-living.com/how-to-prevent-the-coronavirus-covid-19/

"The Chinese Journal of Virology published a review that confirms the antiviral activity of licorice root due to its triterpenoid content."
https://draxe.com/nutrition/antiviral-herbs/

"Scientists from Sun Yat-sen University in China studied the antiviral potential of licorice. They found that several triterpenoids in licorice, such as glycyrrhizic acid, glycyrrhizin, glycyrrhetinic acid and its derivatives, can provide “broad-spectrum antiviral medicine” against herpes virus, HIV, hepatitis virus, SARS coronavirus and influenza virus.

Confirming their findings, researchers from Italy’s University of Padua studied the mechanisms of licorice for viral respiratory tract infections. They found that licorice showed antiviral action against SARS related coronavirus, respiratory syncytial virus by increasing cell membrane protection against the virus, increasing T-cell activity to fight the virus and helping to prevent a latency – or the ability of the virus to hide from the immune system and resume its attack later"
https://www.mywellbeingcompass.com/blog/this-herb-is-clinically-proven-to-inhibit-coronavirus-and-other-lethal-viruses/

"Researchers found that, in addition to inhibiting replication of the virus more effectively than any other drugs, glycyrrhizin also inhibited ability of the virus to infect healthy cells. The authors also commented that glycyrrhizin had previously been used in the treatment of patients with HIV and chronic hepatitis C. Compared with the other agents tested, glycyrrhizin has the lowest occurrence of side effects: only increased blood pressure in susceptible individuals with long-term use."
http://doctorvolpe.com/viruses/licorice-root-extract-found-to-inhibit-replication-of-the-sars-virus/

"Eventually, all the compounds in licorice may be found to be of some medicinal service, but current research focuses on a few of these, namely glycyrrhizin (GL), glycyrrhizic acid (GA), liquiritigenin (LTG), licochalcone A (LCA), licochalcone E (LCE) and glabridin (GLD), the main active components that have been found to possess antiviral and antimicrobial activities 7. The antiviral components appear to be the triterpenoids glycyrrhizin (GL) and glycyrrhizic acid (GA)."
https://www.botanicalmedicine.org/licorice-root-antiviral-antimicrobial-antifungal/

"Licorice root contains triterpenoid saponins, including glycyrrhizin. Researchers have demonstrated that glycyrrhizin is active against severe acute respiratory syndrome (SARS) Coronavirus as well as human immunodeficiency virus (HIV and herpes simplex virus(4). Glycyrrhizin from licorice roots has been shown to inhibit SARS-CoV replication with a 50% effective concentration 365µM and a number of glycyrrhizin derivatives have been shown to possess modestly higher antiviral bioactivity."
https://www.westernherbalmedicine.com/herbal-medicine/119-herbal-medicine-treatment-for-coronavirus.html

"Studies have shown that glycyrrhizin, a compound found in licorice root was more effective in fighting samples of coronavirus from SARS patients than four antiviral drugs. It reduces viral replication, cell absorption, and the virus’s ability to penetrate cells. It is also being used to treat HIV."
https://www.organiclifestylemagazine.com/how-viruses-work-and-how-to-prevent-and-eliminate-them-naturally

"In our studies, we found that glycyrrhizin, the major component of licorice root extracts, could moderately inhibit PEDV infection in Vero cells, when analyzed by western blot, qRT-PCR and a plaque formation assay. We also revealed that glycyrrhizin inhibited the entry and replication of PEDV."
https://pubmed.ncbi.nlm.nih.gov/28175983/

"The active constituents glycyrrhizin and glycyrrhetinic acid activate interferon by the immune system which has strong antiviral activity. Licorice root has also been shown to inhibit the growth of many viruses including herpes simplex type."
https://markstengler.com/natural-alternatives/natures-virus-killers/