"cannabidiol (CBD), a compound produced by the cannabis plant, inhibits SARS-CoV-2 infection. CBD and its metabolite, 7-OH-CBD, but not congeneric cannabinoids, potently block SARS-CoV-2 replication in lung epithelial cells. CBD acts after cellular infection, inhibiting viral gene expression and reversing many effects of SARS-CoV-2 on host gene transcription."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987002/
"CBD, and its active metabolite, 7-OH-CBD, as potential preventative agents and therapeutic treatments for SARS-CoV-2 at early stages of infection."
https://pubmed.ncbi.nlm.nih.gov/33758843/
"Researchers in Chicago say cannabidiol (CBD) keeps SARS-CoV-2, the virus causing COVID-19, from replicating in the lungs and causing severe damage."
https://www.studyfinds.org/cbd-covid-19-prevent-lung-damage/
"CBD has been shown to downregulate proteins responsible for viral entry and to inhibit SARS-CoV-2 replication. Preclinical studies have demonstrated its effectiveness against diseases of the respiratory system as well as its cardioprotective, nephroprotective, hepatoprotective, neuroprotective and anti-convulsant properties, that is, effects that may be beneficial for COVID-19."
https://pubmed.ncbi.nlm.nih.gov/33671463/
"One way CBD appears to reduce the "cytokine storm" that damages the lungs and kills many patients with COVID-19 is by enabling an increase in levels of a natural peptide called apelin, which is known to reduce inflammation and whose levels are dramatically reduced in the face of this storm."
https://medicalxpress.com/news/2020-10-cbd-lung-covid-peptide.html
"This new study has potentially found why CBD has been correlated with these outcomes, noting that apelin levels drop before a cytokine storm and that CBD increases apelin levels. The researchers note that in the ARDS lab model, apelin peptide levels reached near to zero, but skyrocketed 20 times with CBD."
https://www.slashgear.com/study-links-cbd-to-peptide-that-helps-protect-lungs-from-covid-19-20643534/
"Using artificial 3D human models of oral, airway, and intestinal tissues, they identified 13 high-CBD C. sativa extracts that decrease ACE2 protein levels.
Some C. sativa extracts down-regulate serine protease TMPRSS2, another critical protein required for SARS-CoV-2 entry into host cells."
https://scitechdaily.com/medical-cannabis-to-prevent-treat-covid-19-high-cbd-sativa-extracts-modulate-ace2-expression/
"While more work, including clinical trials to determine optimal dosage and timing, is needed before CBD becomes part of the treatment for COVID-19, researchers at The Dental College of Georgia and Medical College of Georgia have early evidence it could help patients showing signs of respiratory distress avoid extreme interventions like mechanical ventilation as well as death from acute respiratory distress syndrome."
https://jagwire.augusta.edu/cbd-may-help-avert-lung-destruction-in-covid-19/
Cannabis compound inhibits SARS-CoV-2 replication in human lung cells
https://www.news-medical.net/news/20210314/Cannabis-compound-inhibits-SARS-CoV-2-replication-in-human-lung-cells.aspx1