Trimeric
- gp160 peptide antigen
- gp41 peptide antigen
- gp120 peptide antigen
Fusion Peptide
- "(HIV-1) and its fusion peptide are essential for cell entry and vaccine design."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382815/
"the antigen to which the immune system responds is a relatively small number of amino acids or peptide."
https://www.who.int/teams/health-product-policy-and-standards/standards-and-specifications/vaccine-standardization/synthetic-peptide-vaccines
"a protein—or even just a piece of a protein—that triggers an immune response inside our bodies."
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/mrna.html
"The human immunodeficiency virus-type 1 (HIV-1) envelope glycoproteins interact with receptors on the target cell and mediate virus entry by fusing the viral and cell membranes. The structure of the envelope glycoproteins has evolved to fulfill these functions while evading the neutralizing antibody response."
https://pubmed.ncbi.nlm.nih.gov/9632381/
The SARS-CoV-2 Spike Glycoprotein as a Drug and Vaccine Target: Structural Insights into Its Complexes with ACE2 and Antibodies
https://pubmed.ncbi.nlm.nih.gov/33105869/
"The trimeric envelope glycoprotein of HIV-1, composed of gp120 and gp41 subunits, remains a major target for vaccine development."
https://pubmed.ncbi.nlm.nih.gov/23602427/
"Antibody responses to the HIV-1 envelope glycoproteins can be classified into three groups."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834917/
"The HIV envelope glycoprotein (Env) binds to cell surface–associated receptor (CD4) and coreceptor (CCR5 or CXCR4) by one of its two noncovalently associated subunits, gp120. The induced conformational changes activate the other subunit (gp41), which causes fusion of the viral with the plasma cell membranes resulting in delivery of the viral genome into the cell and initiation of the infection cycle"
https://www.sciencedirect.com/science/article/pii/S1054358907550027
"HIV envelope proteins include gp41, gp120, and gp160.2 GP stands for "glycoprotein". Glycoproteins have carbohydrate, or sugar, components as well as a protein backbone. The number after the gp refers to the proteins' length."
https://www.verywellhealth.com/what-are-hiv-envelope-proteins-3132617
"Gp120 is essential for virus entry into cells as it plays a vital role in attachment to specific cell surface receptors."
https://en.wikipedia.org/wiki/Envelope_glycoprotein_GP120
"Gp41 also known as glycoprotein 41 is a subunit of the envelope protein complex of retroviruses, including human immunodeficiency virus (HIV). Gp41 is a transmembrane protein that contains several sites within its ectodomain that are required for infection of host cells. As a result of its importance in host cell infection, it has also received much attention as a potential target for HIV vaccines."
https://en.wikipedia.org/wiki/Gp41
"The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein is synthesized as a precursor glycoprotein, gp160, and is then processed into gp120 and gp41."
https://pubmed.ncbi.nlm.nih.gov/8178478/
"The design, development, and testing of a successful HIV-1/AIDS vaccine formula are a continuing endeavor over the last two decades."
https://link.springer.com/chapter/10.1007/978-3-319-95327-4_9