What is a peptide vaccine?

in medical •  4 years ago 

"A peptide is a kind of small protein consisting of two or more amino acids linked together in a chain."
https://docs.google.com/document/d/1Xk5S0DwdXy8bVY30PJA07Z_uWcXr5P6Ejt4cJj3pNBw/mobilebasic

"A peptide vaccine is any peptide which serves to immunize an organism against a pathogen. Peptide vaccines are often synthetic vaccines[1] and mimic naturally occurring proteins from pathogens"
https://en.wikipedia.org/wiki/Peptide_vaccine

"Peptides are short strings of amino acids, typically comprising 2–50 amino acids. Amino acids are also the building blocks of proteins, but proteins contain more."
https://www.medicalnewstoday.com/articles/326701#uses

"Peptide vaccines are considered an alternative to classical vaccines that are trying to address issues of possible vaccine side effects related to vaccination with a heterogeneous multicomponent preparation."
https://www.sciencedirect.com/topics/neuroscience/peptide-vaccine

"Most existing vaccines are prepared from an attenuated version of the pathogen or from inactivated disease-causing organisms or a suitable part of it e.g. a toxin. However, often the antigen to which the immune system responds is a relatively small number of amino acids or peptide."
https://www.who.int/biologicals/vaccines/synthetic_peptide_vaccines/en/

"Peptide antigens are less likely to induce allergic or autoimmune responses due to the lack of redundant elements."
https://pubs.rsc.org/en/content/articlehtml/2016/sc/c5sc03892h

"peptide antigens are used because they are part of a larger protein, which may not have been purified. When using a peptide antigen to make antibodies, it is important that a researcher use an antigenic section of the peptide. Antigen specialists can help with antigen design to maximize the chances that the peptide used as antigen will generate an antibody"
https://www.wisegeek.com/what-is-a-peptide-antigen.htm

"In general, antigens are composed of proteins, peptides, and polysaccharides. Any portion of bacteria or viruses, such as surface protein, coat, capsule, toxins, and cell wall, can serve as antigens."
https://www.news-medical.net/health/What-is-an-Antigen.aspx

"In particular a self-assembled peptide vaccine containing a tuberculosis epitope maintained all of its potency in mice when exposed to an extreme thermal treatment of six months at 45°C."
https://pubmed.ncbi.nlm.nih.gov/26584836/

"Multiple antigen-presenting peptide vaccine systems have been developed to avoid the adverse effects associated with conventional vaccines (i.e., live-attenuated, killed or inactivated pathogens), carrier proteins and cytotoxic adjuvants."
https://bmcchem.biomedcentral.com/articles/10.1186/1752-153X-5-48

"the use of only minimal antigenic epitopes which can trigger the desired immune responses appears to be the smart approach to develop safe vaccines. The synthetic peptide-based vaccines may have such a capacity. They may become the unique medication of the future capable of delivering not only protection against diseases but may turn into the therapeutic tool to treat them."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529997/

"The stability of each peptide is unique and is dependent on its sequence."
https://www.genscript.com/peptide_storage_and_handling.html

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