Researchers uncover genetic basis of natural variation in aging rate

By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Aging is characterized by a progressive decline in physiological functions and is a major risk factor for neurodegenerative disorders, cancer, and diabetes. Previous studies on aging mainly focused on the regulation of longevity, and more than 100 genes and numerous small compounds have been identified that regulate lifespan in organisms from yeast to mammals.

Lifespan extension induced by genetic mutations has been shown in recent studies not to necessarily delay age-related behavioral decline, suggesting that longevity and behavioral aging may be two dissociable processes. With the increase of life expectancy, prevention of age-related functional impairment has emerged as a major challenge. Despite the great advance in genetic control of animal lifespan, little was known about the regulatory mechanisms of healthy aging, i.e., aging with limited loss of physiological function.

Now, a new study carried out by researchers from Dr. CAI Shiqing’s lab at the Institute of Neuroscience, CAS Center …

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(2017-12-02), Researchers uncover genetic basis of natural variation in aging rate, Obesity, Fitness & Wellness Week, 3211, ISSN: 1532-4664, BUTTER® ID: 014746298