(CNN)Coronavirus cases in the United States reached another daily high Thursday with 185,759 new infections, according to Johns Hopkins University data.
The previous record of 177,224 was set Friday.
More than 252,000 people have died of Covid-19, the disease caused by the virus, and the US Centers for Disease Control and Prevention's ensemble forecast now projects the country's Covid-19 death toll could reach between 276,000 and 298,000 by December 12 -- just weeks after the US surpassed the 250,000 mark on Wednesday.
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The CDC's ensemble forecast, which offers projections for the next few weeks, previously projected up to 282,000 deaths by December 5.
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"The number of deaths that we're going to see in three weeks' time or four weeks' time reflects the actions that we all take right now," said Dr. Leana Wen, an emergency physician and the former Baltimore health commissioner. She urged Americans to have a safe Thanksgiving holiday -- or plan to have one in July.
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"I understand that people are worried, they're stressed, they haven't seen their loved ones, they want to see their loved ones now more than ever," she said. "But we really cannot do that in person, indoors, safely this Thanksgiving."
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Wen's comments came as the CDC recommended Thursday that Americans should not travel for the Thanksgiving holiday. Dr. Henry Walke, the agency's Covid-19 incident manager, pointed to the current "exponential growth in cases and the opportunity to translocate disease or infection from one part of the country to another."
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"One of our concerns is people over the holiday season will get together and they may actually be bringing infection with them to that small gathering and not even know it," Walke said on a call with reporters.
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Numbers are headed in the wrong direction across the country, according to a CNN analysis of data from Johns Hopkins University.
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Only one US state, Hawaii, is showing a decrease in new cases greater than 10% compared to the previous week. Five others -- Idaho, North Dakota, Iowa, Illinois and Arkansas -- are holding steady, while the remaining 44 states are showing increases in new cases greater than at least 10% compared to the week prior.
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Nationwide, the seven-day average of new cases is at its highest ever: 161,165 cases a day. That's up 27% compared to last week.
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An early cold snap in the middle of the country at the end of September helped drive the recent surge in cases as people moved indoors, Dr. Deborah Birx, the White House coronavirus task force coordinator, said Thursday.
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Birx asked Americans to limit gatherings, stay apart and wear masks -- including indoors, she said, because of the possibility of asymptomatic spread.
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"This is more cases, more rapidly, than what we had seen before," she said in a White House coronavirus task force briefing Thursday -- the first such briefing since July 8.
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"We're asking every American to remain vigilant," she said, "to do those things that we have been asking you all to do: to wear a mask, to physically distance, continue your hand hygiene."
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According to Johns Hopkins, at least 11.6 million infections have been reported across the US.
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Thanksgiving week will be critical
The end of the pandemic may be in sight thanks to good news about vaccine candidates, but things will likely get worse before they get better, according to Adm. Brett Giroir, assistant secretary for health at the Department of Health and Human Services.
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A final analysis of the Phase 3 trial of Pfizer's Covid-19 vaccine shows it was 95% effective in preventing infections, even in older adults, and caused no serious safety concerns, the company said Wednesday. It said it will seek a US Food and Drug Administration emergency use authorization "within days."
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The Pfizer analysis came just days after a separate vaccine maker, Moderna, released early data showing its vaccine was about 95% effective.
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Giroir told CNN he was optimistic about the potential for two apparently effective vaccines, calling it "our end game."
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"That being said," he added, "this will get worse."
Just how bad it gets will be determined by Thanksgiving celebrations next week. Health officials and local leaders have warned against traditional holiday gatherings, saying those will likely help further drive the surge of cases.
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But Americans can make the holidays a turning point, by masking up and following other safety precautions, the Infectious Diseases Society of America said Wednesday.
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"Virtual gatherings remain the safest way to bring friends and family together from distant points. Outdoor settings can reduce the risks of gatherings with people outside of your household," the group said, also highlighting the importance of face coverings.
"We have the resources and the knowledge to stem the spread of this pandemic. Keeping our common cause and shared well-being at the forefront of our holiday celebrations will make a difference."
Dr. Anthony Fauci, the nation's top infectious disease expert, urged Americans to "double down" on public health measures such as wearing masks and avoiding gatherings until vaccines are available.
"If you are fighting a battle and the cavalry is on the way," Fauci said, "you don't stop shooting until the cavalry gets here."