Cannabidiol (CBD) & Leukemia

in news •  2 years ago 

"The study also included that CBD was shown to cause cell death in Leukemic cells and reduce tumor size in mice (Alharris, Singh, Nagarkatti, Nagarkatti, 2019)."
https://beescannafarm.com/blogs/news/cbd-and-neuroblastoma-and-leukemia-cell-death

"Anticancer properties of non-psychoactive cannabinoid cannabidiol (CBD) have been demonstrated on tumors of different histogenesis. Different molecular targets for CBD were proposed, including cannabinoid receptors and some plasma membrane ion channels. Here we have shown that cell lines derived from acute lymphoblastic leukemia of T lineage (T-ALL), but not resting healthy T cells, are highly sensitive to CBD treatment."
https://pubmed.ncbi.nlm.nih.gov/31611561/

"CBD primarily targets mitochondria, inducing a stable mitochondrial permeability transition pore (mPTP) and, consequently, the death of acute lymphoblastic leukemia (T-ALL) cells."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8395529/

"CBD have previously been shown to have opposing effects on cells. Thus, 1 µM CBD induces proliferation of T leukemia cells, but at higher concentration kills the cells [9]."
https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-020-05229-5

Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression
https://pubmed.ncbi.nlm.nih.gov/16754784/

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