An idea that a think people don't parse out enough is that the gnostic/agnostic thing is a modifier that can be applied to atheism or theism. I think sureness about things we can't really ever have knowledge of (especially not in any complete way) is a bigger folly than believing or not believing in gods or no gods, so whether one is an atheist and transhumanist or a theist, anything other than agnosticism is pretty foolish. As I once read, "religion is philosophical suicide"; this goes for pseudo-scientific religion as much as more the transparently spiritual.