Science Brief: Does Eating Broccoli Make Arthritis Better? Updated: It Also May Help With Diabetes

in science •  7 years ago  (edited)

So I have recently been trying out some, no-background, no nonsense science posts about current topics in the literature. This series has been well received, so today I have returned to follow this protocol yet again and hopefully produce for you something that is both interesting and not a big time investment!

For this post let us turn to a topic that I file under the category of pleasantly surprising. The article we will briefly discuss was published in the journal Nature: Scientific Reports and is titled "Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint."


Broccoli Is A Super Food

We all know that broccoli is a SUPER FOOD right? It's quite healthy for us, high in nutrients, high in fiber, low in calories. Tastes great (especially with cheese!!!), what's not to love?

The internet (and science too) is full of wild claims about the wondrous health properties of broccoli. It Fights Cancer due to the compound sulforaphane. Interestingly this particular compound is also thought to help prevent arthritis [3] due to its protective properties of cartilage (in our joints!)

What Were The Authors Studying?

They were continuing to study broccoli in relation to arthritis, specifically this compound solforaphane. Solforaphane (or 1-isothiocyanato-4-methylsulfinylbutane) is a compound that is produced in our bodies through processing of another compound called glucoraphanin, which is made by broccoli. Now as I mentioned there have been a variety of previous studies on solforaphane where people have identified quite a bit about how it accumulates in the body after eating broccoli (including in people on a high broccoli diet). [4], [5]. What researchers have also found is that despite the fact that this compound accumulates in the body, there is no known toxicity issue from consuming normal amounts of broccoli in the diet, even indefinitely.


This is what solforaphane looks like

In this study the authors wanted to see if the arthritis and joint protection from this compound were derived from it actually accumulating in those locations, or if the effect was due to it's work elsewhere in some other biochemical pathway.

Briefly What Did They Find?

  • People who ate more broccoli (which was high in the glucoraphanin) compound has higher levels of isothyocyanate compounds in their blood (this is the class that solforaphane belongs to), with an increase in solforaphane specifically noted.
  • In this study people who were eating a high glucoraphanin broccoli diet did not show a reduction in cartilage damage
  • However the people eating the high broccoli diet did have itothyocyanates found in the fluid between their joints (synovial fluid), while the control group did not.
  • They also saw a change in the protein composition in these synovial joint fluids, for only those on the high broccoli diet.

Conclusions

The authors illustrated in this article for the first time that broccoli consumption results in an accumulation of Solforaphane and other isothyocyanate compounds in joint fluid (these are the protective compounds), and noted a change in the protein composition of these fluids. These findings support prior research indicating that solforaphane has a direct joint protective activity. A number of these protein composition changes were reductions in ones which have been previously identified to associate with conditions like rhumatoid arthritis such as Calreticulin, which is found in higher levels in the joints of those suffering from arthritis [6]. The authors findings here illustrate potential mechanisms by which the protective properties of solforaphane might come.

I Have Arthritis... Should I Eat More Broccoli?

Well according to this article the answer isn't just broccoli as the control group here was also eating it. Rather the key was the group eating broccoli that was high in glucoraphanin. Beyond this, there are no guarantees of miracle cures, or that if you are eating broccoli that is high in glucoraphanin you won't develop arthritis. Nevertheless, considering all of the other health benefits associated with eating this nutrient dense veggie, it doesn't seem like the worst plan to try to incorporate it into your diet if you don't already eat it, or to try to eat it regularly if you already do ( I know I eat broccoli all the time! Yay me! )

Additional Interesting Research Edit 6-15-2017

A recent article published in the journal Science: Translational Medicine titled "Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes". Studying the very same compound Sulforaphane, which we discussed in this post originally, has found that high concentrations (administered in a pill) had a beneficial effect on blood glucose levels in diabetics. As far as the effect from consumption of broccoli is concerned, you would have to eat 5 kilograms of it daily, to get a comparable amount of the compound in your system (and I don't think anyone is going to start eating that much broccoli... sooo much fiber). So this is not something to think too much about (from a nutrition standpoint) nevertheless it is just another positive aspect of broccoli and these isothyocyanate compounds that it produces.

Sources

  1. https://www.nature.com/articles/s41598-017-03629-5
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777483/
  3. https://www.ncbi.nlm.nih.gov/pubmed/23983046
  4. https://www.ncbi.nlm.nih.gov/pubmed/16332662
  5. https://www.ncbi.nlm.nih.gov/pubmed/11751429
  6. https://www.ncbi.nlm.nih.gov/pubmed/20533543
  7. http://stm.sciencemag.org/content/9/394/eaah4477

All Non Cited Images Are From Pixabay.com or Flickr.com And Are Available Under Creative Commons Licenses

Any Gifs Are From Giphy.com and Are Also Available for Use Under Creative Commons Licences


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I have upvoted and resteemed the post. Cheers.

Thank you :)

Very good post backed up with scientific evidences in those published articles. I started eating broccoli like crazy about 3 years ago when it was clear to me that I would need to go for a major gynecological surgery (myomectomy including cystectomy). The issues I had were as a result of estrogen dominance. Brocolli helped me a lot to reduce bloating in my stomach, so much so that a girlfriend of mine noticed it and asked me what I was eating. I told her that every evening, for dinner, I was eating steamed broccoli with fish drizzled with a teaspoon of cold pressed hemp seed/olive oil. The indole-3-carbinol in broccoli is responsible for assisting the liver to clear excess estrogen. It's quite interesting to know from your post that broccoli also helps relieve arthritis. Well done, @justtryme90!!! Thank you for sharing.

Broccoli has quite a few good aspects to it, biochemically speaking. In addition to it's high fiber and general vitamin and mineral content. Truly of the best vegetables.

Absolutely, it is! Guess what? Your broccoli blog post was a very good reminder that it was time for me to prepare cream of broccoli soup, which I have just done. Here, the link https://steemit.com/food/@maryfavour/how-to-prepare-cream-brocolli-soup-using-soup-maker-part-1 . Thanks for the reminder.

Mmm broccoli soup :D

Cruciferous vegetables if you don't (just) like brocolli.

The amount of glucorphanin is not consistent across all cruciferous veggies, so while that may be somewhat true, it is not entirely consistently true. This article seems to indicate that as far as the protective activities reported here are concerned that high glucorphanin is necessary. Broccoli happens to be particularly high in this particular compound, when compared to other similar vegetables. I linked a source to this info in a different comment.

Very thorough.. esp. sighting all your sources.. I wonder how many other Cruciferous vegetables contain glucoraphanin ? I'm pretty sure broccoli, cabbage, brussel sprouts, cauliflower, and a few others are all hybridizations of the Sea Cabbage plant..

Thanks for the link…

  ·  7 years ago (edited)

Brassica oleracea is a plant species that includes many common foods as cultivars, including cabbage, broccoli, cauliflower, kale, Brussels sprouts, collard greens, savoy, kohlrabi, and gai lan.

In its uncultivated form, it is called wild cabbage, and is native to coastal southern and western Europe.

https://en.wikipedia.org/wiki/Brassica_oleracea

Broccoli is delicious but if you have a thyroid condition,you should be aware of how long you cook your broccoli. Broccoli(and other cruciferous vegetables)contains goitrogens which can potentially have an impact on thyroid function, so make sure you cook your broccoli for a good 30 minutes.

https://en.wikipedia.org/wiki/Cruciferous_vegetables

Also, why would you put cheese on broccoli? You're ruining it! ;-)

The jury is still out on thyocyanates (goitrogens just refers to any compound that can damage the thyroid, lets be more specific) and thyroid function.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135245/

The cited article here is a review, in which they discuss the findings of a variety of articles. Some of the articles published on the subject found a positive correlation between thyroid cancer and consumption of cruciferious vegetables (like broccoli), others saw no correlation, some saw a correlation, but only if the person had an iodine deficiency in their diet. At this point I don't think there is a very clear link between broccoli consumption and thyroid troubles.

you should be aware of how long you cook your broccoli

well if you want to break down the thyocyanates then yes longer cook times will degrade the compounds, however these very same compounds are the ones discussed in this article with arthritic protective activities (Solforaphane is one of these compounds, and is the subject of this entire post!)

Also, why would you put cheese on broccoli? You're ruining it! ;-)

I like to do lots of things with it. Sometimes I like to add cheese with broccoli, its tasty. Roasting broccoli with some fresh garlic is also tasty. I mean there are a lot of things you can do with it other than just plain old steamed (which is also fine). I it raw too. :)

Thank you for that.

My G.P was the first person to tell me about the broccoli/thyroid link but there's no way I'm giving up my broccoli! At the end of the day, there are more pro's than con's to eating broccoli . Bring on the broccoli!

This is the case with so many aspects of life. Everything has benefits and drawbacks. If the benefits far outweigh the drawbacks then one should still go for it. Broccoli has just way too much good going for it. Heck yeah, bring on the broccoli!

loved ur article justtryme90, have u heard of sick building syndrome I think this article is important https://steemit.com/health/@whitedolphin/is-your-building-making-you-sick#comments

Thanks. Yeah I know of that, it's pretty logical that moldy dwellings are not good for general well being :)

Excellent article! Followed you!

Great post

We appreciate that you mentioned all the sources. Keep posting great content you are helping the community. ; )

I will try my best to be informative and leave the trail of breadcrumbs for others to follow and research into further, thank you for your support @health-trail.

Good news, broccoli is about the only vegetable I eat!!

Thats called winning man. :)

Couldn't agree more haha.

  ·  7 years ago (edited)

(Edited: Oop, I see some people already posted this fact!) Good stuff! I was just reading about how broccoli was developed from the same original species as so many other vegetables we eat today. It turns our broccoli, broccolini, cauliflower (ok no surprises yet right?), kale, cabbage, brussel sprouts, collard greens, and more are just cultivars/varieties of the same species. https://en.wikipedia.org/wiki/Brassica_oleracea

Yep broccoli are a nice result of traditional plant breeding.

If prevention is found more often then causation then it prevents. If causation is found more often the prevention then it's a causative agent. Experiments are complicated, methods aren't always good. That figure is a bit disingenuous don't you think? ;)

Actually, it very much is. It's polemic and exaggerates a lot.

On a more serious note however I would like to emphasize that this study was performed on 40 patients only. It might contain some valuable insights but IMO it also has to be treated with caution as 40 is a pretty small sample size.

P.S: I'm not trying to mess with you here. Your article is very well written and the study seems to have been performed with great care. However, it's just too early to draw any conclusions from it without further investigations.

Broccoli is awesome! Whats funny is that when I was younger I use to hate broccoli like with a passion but now it's one of my favorite veggies. I have no idea how that happened but it did.

The very same thing happened with me! I don't know what it is about it but it used to taste terrible to me.. but now I honestly crave it.

could be associated with microbiota alteration? :)

I could only be so lucky. That a microbiome alteration leads to me wanting to make healthier choices. :D

same it happened for me with vegetables in general. but I guess it's a matter of habituation as well.

Yeah I haven't actually given it all much thought to be honest ( with regards to my preference changes ). It's likely a multitude of factors.

I am on the same boat as you too, guys. I never liked it before, but after my 25th birthday I started eating it, and now I like it so much, I could eat it everyday.

Great post

Another great post from @justtryme90 . You are amazing Man. It's always a honor to read your articles, broccoli that is high in glucoraphanin you won't develop arthritis. Although I don't have arthrites but It's always good to know.

Anything with cartilage protecting activity should also logically have benefits for a runner such as yourself as well. :)

Oh Great. Actually I injured myself by intensive running. I am making my cartilage strong by cycling these days. ; )

Actually I injured myself by intensive running.

Sorry to hear this.

I realized that when it start to pain. So I took rest for about 2 weeks till now and now cycling and making it a bit strong. And I am eating a special diet in morning, What I do is I take almonds, Peanuts, Pulses like dal, white and black chickpea, walnuts and some other things and leave them in water and eat them in morning. : )

Apparently you should add some broccoli to your special diet.

I do think so after reading all this.

that's a wow from me.....

Thank you :) I always appreciate your kind words.

you are welcome....my friend...

Bro-occoli @ironshield

Haha, awesome. Thanks for your comment.

From now on...... I'll eat them all!!!!!

Sounds like a good plan to me :)

seaweed is great for arthritis too -- i have just got back from Japan and found out a lot about the weed. Anyway i like your advice about brocilly too cause all those from the broclacasy family help prevent cancer of the bowel as well.. i am now following you and i hope you drop in and check out my music and art -David

Thank you David! I have followed back so you should be in my feed going forward.

so interesting! that will help many members of my family! great post!

Thanks, I'm glad you enjoyed it and found it helpful.

Great article ...
Basically it's the Sulfur in cruciferous vegetable,alliums ,and edible stalks .
One might consider taking MSM if sulfur is the desired nutrient but Broccoli is
still a great superfood.

It's my favorite vegetable by far.

I love to roast broccoli with some fresh garlic a little butter and some salt. mmmm

Oh Yeah !!

wow!!!great!!!!

Thanks for reading, I'm glad you enjoyed the post.

welcome

Good post! Upvoted and followed you.

Thanks for reading :)

I'm glad you enjoyed the post.

Good one @justtryme90 my mom has this issue..very informative! Thank you very much!

Joint pain is something that many people suffer from. It's no fun.

Concise and fun, nice read :)

Thank you!

  ·  7 years ago (edited)

It helps constipation !
Oh I am kidding!

It does though!

I would imagine it does, fiber is good for constipation.

By the way,I have upvoted your post,can you upvote my new post(https://steemit.com/money/@wallsnow/introducing-randowhale-get-whale-power-by-sending-steem-stemm-dollar) also?Thanks

I will say 1 thing related to arthritis, and 1 thing related to broccoli.

Arthritis: I've heard CBD (Cannabidiol) is great for arthritis and similar painful medical conditions.

Broccoli: I'm not sure about helping with arthritis, although your conclusions would suggest it does help. But what I have to say is this: I'm not sure if Broccoli makes arthritis better, but it makes my flatulence worse LOL great post by the way!

but it makes my flatulence worse LOL

That's all the fiber :)

It is a very good source of dietary fiber and rich of pantothenic acid, vitamin B6, vitamin E, vitamin B1, vitamin you can enjoy it anytime .u can blend and make a broccoli juice with honey blend.

Yep, it's a pretty great vegetable.

This is great, I thought I was too young to have arthritis but here I am trying to find ways to feel better. Upvoted!

Thanks for reading, glad you liked the post.

While there is not guarantee that this will help arthritis it wouldn't hurt to add this to your diet. Overall, this would make you more healthy and at least give you a chance of preventing or lessons symptoms!

Indeed, broccoli is a healthy choice regardless of this. It's only a good addition to our diets.

Excellent indeed. I love the green stuff. Planted it in my garden this year. All and any of the green vegetables are cancer fighting vegetables. Keep the posts coming about natural medicine and the power of the plant. Thanks for sharing

I should have planted some this year too, but I grow out of pots. I don't know how much broccoli likes growing in a pot. Hmm.

Broccoli will thrive in a bucket. Lots of sun and plenty of water like daily.

Hmm, maybe I'll run to the store this weekend and pick up a small plant. Probably too late to grow from seeds. Thanks!

Lots of time to grow from Seed. Good luck

Fun Science-y fact : The main reason Broccoli helps arthritis is because arthritis is worsened by inflammation and broccoli has way more Omega-3 than Omega-6 and generally reduces Omega-6 consumption in the diet

This isn't to say fish is good for this however due to contaminates in it, as well as most high Omega-3 fish has tons of Omega-6 too.
The best solution is vegetables, fruits are good too, and some Chia/Hemp/Flax seeds regularly :)

Broccoli has a variety of compounds that reduce inflammation other than Omega-3 fatty acids as well.

Well... Not sure. Not a big believer in these brocoli diets and such. I see some parents forcing the stuff on their kids and, well... I doubt it has any extra benefits.

I just wrote a story here on Steemit about something I witnessed back in 2011, the Fight At The Long Beach Pier

I don't know about crazy diets either. I don't think it's clear as of yet precisely the conditions necessary for beneficial effects. It does seem clear that one is possible however.