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Multi-distance algorithms
Multi-distance algorithms measure from two or more tissue depths and incorporate the diffusion equation to allow a % absolute tissue saturation index (TSI; also termed tissue oxygenation index) to be calculated. Spatially resolved spectroscopy (SRS) and the self-calibrating (SC) method are the 2 main multi-distance approaches. The slope of light attenuation versus source-detector separation distance is determined, from which the absorption coefficient can be calculated by applying diffusion theory. The tissue is assumed to be homogeneous in these methods and the scattering coefficient is modelled according to the light wave-length. Thus, these methods are thought to account for the influence of superficial tissue layers; hence TSI values can be compared directly between subjects. A correction factor for TSI can be calculated by placing a third light source directly between the first and second source; attenuation at the middle distance should be intermediate between the shortest optode-detector distance and the longest (Personal communication: Portamon, Artinis Medical Systems, The Netherlands).
Signal components