Alex Oxlade-Chamberlain, Roberto Firmino, Sadio Mane and Mohamed Salah were all on target as Liverpool beat Manchester City 4-3.
Liverpool left Manchester City's unbeaten Premier League record in tatters with a thrilling 4-3 win over the leaders.
Anfield has long provoked a sense of dread for City, who last won at the Merseyside ground in May 2003, and they collapsed under an unsustainable weight of individual errors as Liverpool ran amok after half-time.
Alex Oxlade-Chamberlain produced a midfield performance to thrill the Liverpool faithful in the wake of Philippe Coutinho's departure to Barcelona and opened the scoring with an excellent ninth-minute opener on an afternoon of high-class finishing.
Leroy Sane thrashed a shot beyond Loris Karius at the near post to draw City level five minutes before half-time and Jurgen Klopp's choice of goalkeeper might have come in for greater scrutiny had the three attacking stars Coutinho left behind not sparkled at the other end.
Roberto Firmino's 10th Premier League goal of the season arrived courtesy of a deft finish in the 59th minute and Sadio Mane added a third 126 seconds later, having found time to hit the post in between.
City were a mess as Mohamed Salah completed a dizzying spell of three goals in nine minutes and, although Bernardo Silva and Ilkay Gundogan set up a grandstand finish, Liverpool deservedly inflicted a first defeat upon Pep Guardiola's side in 23 top-flight games this season.
Salah recovered from a hamstring injury as expected to line up in the Liverpool attack and John Stones got across well to block a shot from the Egypt star after Firmino and Mane tested City's high defensive line in the fourth minute.
Raheem Sterling went down softly in the area and was predictably booed by the Anfield faithful, who were soon sent into raptures by Oxlade-Chamberlain.
There appeared to be little danger when the former Arsenal man collected a loose ball 30 yards from goal but he glided effortlessly past Fernandinho before arrowing a brilliant drive across Ederson and into the bottom left corner.
The visitors were struggling to assert themselves as an attacking force but Sergio Aguero was just shy of finding a decisive touch on the end of Kevin De Bruyne's delicious 20th-minute cross.
City's task became steeper when Fabian Delph limped off with an apparent knee injury after half an hour. The left-back’s replacement, Danilo, was promptly outmuscled by Oxlade-Chamberlain, who saw Firmino head an inviting cross wide at the near post.
Liverpool appeared to be closing in on a second before the increasingly ragged league leaders were roused by Sane's exquisite talent.
The Germany winger chested down Kyle Walker's searching pass, darted inside Joe Gomez, skipped beyond a squared-up Joel Matip and clattered a strike past Karius at his near post as Gomez slid in vain.