The Immune System: Your Best Friend, Your Worst Enemy

agmoore2 (63) in steemstem • 5 years ago (edited)

Queen Anne of Great Britain (1665-1714)

Queen_Anne_of_Great_BritainRoyal Collection RCIN 405676 public.jpg

Image: Royal Collection, 1736, public domain

It's not possible to know if Queen Anne's face was really as red as it appears in the picture, or if the portrait artists (Godfrey Kneller, followed by Charles Jervas) took liberties and gave her very high color. However, it is an interesting coincidence that historians entertain the possibility that Queen Anne may have been dealing with systemic lupus erythematosus.

Characteristic Malar Rash in Systemic Lupus

malar rash lupus diagram head.jpg

Compare the rash in the drawing above (by CNX OpenStax, and used under a CC 4.0 license) to the ruddy cheeks evident in Queen Anne's portrait. Often called a 'butterfly rash', this distinctive flush is often symptomatic of a lupus flare (acute activation of disease). An acute activation of lupus can involve any system in the body. Though there are "typical" patterns the disease follows, in fact there is no way to know where the disease may appear. In each case, though, the symptoms are a result of the immune system becoming an enemy, rather than a friend. This is the essence of autoimmune disorders. SLE (systemic lupus) is an autoimmune disease.

A 1947 Picture of Flannery O'Connor (1925-1964)
Robie with Flannery 2 1947 Cmacauley at English Wikipedia 1.0, 2.0. 2.5, 3.0.jpg
Image, Cmacauley at English Wikipedia: CC license 1.0, 2.0. 2.5, 3.0

O'Connor experienced her first symptoms of Lupus in the early 1950s. Her father died from the disease in 1941. Treatment with high doses of corticosteroids allowed O'Connor to live, and to write award-winning stories, for another fourteen years. Corticosteroids were used to treat systemic lupus for first time in 1950.

Our immune system is designed to protect us. It is equipped with an army prepared to battle pathogens that manage to breach external barriers, such as the skin, and the mucous membranes (which are also part of the immune system.) Among the dedicated soldiers in our immune army are phagocytes.

Phagocytosis: Attacking and Destroying the Enemy

Phagocytosis2 Process.svg Alexa cottrell 4.0.jpg

The author (Alexa Cottrell] of this illustration offers a summary of the action: An invading microorganism is detected; a phagocyte surrounds and engulfs it; digestive enzymes are released; the pathogen is destroyed.

Complement Complex : Stalwart Sentinels in the Immune System

Another brigade in our immune army is comprised of the complement complex. Circulating throughout our bodies all the time are proteins that stand ready to defend when we are threatened by something perceived as foreign. (Self vs. nonself)

The complement complex is designed to be activated only when needed. The proteins perform in cascading coordination. One of their jobs is to launch a direct assault on an enemy. The proteins can become a kind of A Team in a membrane attack complex--MAC: A pathogen is targeted; the pathogen's surface membrane is compromised by cooperation between four complement components (C5,C6,C7, and C8); and a fifth complement (C9) moves in to deliver a lethal blow. Watch this YouTube video by JohnArt to see a dramatization of a MAC assault.

Diagram of Membrane Attack Complex in Action

Membrane_Attack_Complex_(Terminal_Complement_Complex_C5b-9)SLiva2016 1.2 license.jpg

This diagram, by SLiva2016 (CC 1.2 license), shows complement complex proteins C5, C6, C7, C8, and C9 as they attack the surface membrane of a microorganism. The first four create the environment for C9 to open a pore and introduce bactericide.

Inflammation and Trash Clearance

Two more activities of the immune system are, promote inflammation and clear away debris. Inflammation serves an important function because it alerts different elements in the system that there's danger and they have to come to the aid of imperiled tissue. Also, debris--bits and pieces left around, including killed pathogens--has to be removed or it will endanger healthy tissue.

The Immune System: A Double-Edged Sword

The immune system can hurt us.

Anyone who has ever had an allergic reaction, has experienced the immune system overreacting to a substance. And most of us know someone who is dealing with an autoimmune disorder--diabetes, rheumatoid arthritis, multiple sclerosis, (schizophrenia?), COPD--the list is endless. When people are stricken by one of these diseases, the immune system becomes their enemy, not their friend.

The complement complex plays a significant role in aberrant immune system behavior.

The Membrane Attack Complex (MAC) in Multiple Sclerosis

Immune Cells Attack Healthy Nerve Tissue in MS
demyelination MS adapted.jpg
Image Credit: Adapted from a diagram by BruceBlaus on Wikimedia Commons. Used under CC 4.0 license

Autoimmune disorders present a dilemma to treating physicians and patients: how to stop the immune system's damaging activity without compromising its essential defensive function. Meeting this challenge may explain why one of the most expensive medicines in the world, Eculizumab, is designed to combat an autoimmune disease: multiple sclerosis (Eculizumab also is used to treat other autoimmune diseases). The list price for this medicine is about $500,000 a year--though that price varies by country.

Eculizumab Attaching to Complement C5

GIFCredit:Campylobacter on Wikimedia Commons CC 4.0 international license

By attaching to C5 Eculizumab prevents the complement cascade from going forward--it stops the Membrane Attack Complex from being inflicted on healthy tissue. However, use of the drug does carry with it an increased risk of serious, possibly life-threatening infection.

Bitten by a Coral Snake? The Complement Complex May Kill You

The Membrane Attack Complex is a thing of beauty, but complement complex is a fickle friend. Note the case of snake bite, described below.

Micrurus fulvius, Eastern Coral Snake, Jacksonville, FL
micrurus Coral snake 009 Norman.benton 3.0.jpg
Image: Norman.benton 3.0 Unported license

According to BMC Immunology, if you are bitten by a coral snake, the venom from the snake may activate the complement complex. Instead of coming to your rescue, as would be the case in MAC, the complement cascade will generate a "significant amount of anaphylatoxins". These toxins will aid in the spread of venom throughout your system, and the effects may be fatal.

Cancer: Another Example of the Double-Edged Sword

The immune system may identify, target and destroy cancer cells. Paradoxically, a number of studies have demonstrated that activation of the complement complex in the presence of cancer, may actually promote tumor growth. A 2012 article in Journal of Clinical Investigation describes studies that show the complement complex induces inflammation, which in turn promotes tumor growth.

Systemic Lupus and Its Relationship to the Complement Complex, Especially C4

Ferdinand Marcos (1917-1989), Ronald Reagan and Imelda Marcos, 1982
Marcos visit_Reagan_1982 U.S. government photographer public.jpg
Image by U. S. government employee. Public domain

Ferdinand Marcos fought systemic lupus for many years and died of the disorder in a Hawaii hospital.

I began this blog by talking about Queen Anne and the suggestion that she might have had systemic lupus. Historians and physicians guess this might have been the case because of the constellation of symptoms she evinced. These included not only trouble with blushing, but also many failed pregnancies, dropsy, gout, hemorrhage and stroke It is a patently frustrating exercise to try and diagnose an illness three hundred years after someone has died. With regard to lupus, however, the exercise is almost as frustrating when it is conducted in the present.

There exists no single lupus test. Usually, a diagnosis is made by observing symptoms and by performing a series of agreed upon laboratory tests. One of these tests is to assess complement levels, It turns out that a particular complement, C4, is associated with lupus--and a number of autoimmune diseases.

Chart of Some Autoimmune Diseases and C4 Association

table autoimmune1.jpg
My chart, assembled from sources listed at the end of this blog. Anybody can use the chart for any reason.

One of the reasons I included chromosome association is because autoimmunity often has a genetic link, though perhaps not a genetic cause. It's interesting that C4 itself is located on Chromosme 6, which seems to pop up in a lot of the associations on the chart.

Take Out the Trash!

Somewhere in the middle of this blog I mentioned that the immune system is charged with housekeeping, with removing debris. A lot of this debris is dead cells, some of these killed through trauma, some that die naturally.

Scheduled cell death is called apoptosis. According to an article in Frontiers in Autoimmunity, Clearance Deficiency and Cell Death Pathways: A Model for the Pathogenesis of SLE: "Defects in the clearance of apoptotic cells may be responsible for the initiation of systemic autoimmunity in several chronic inflammatory diseases, including systemic lupus erythematosus (SLE)". The article explains that C4 plays an important role in clearing apoptotic cells. Therefore, low levels of C4 may contribute to the accumulation of the debris and may consequently promote the inflammatory disease process.

Apoptosis Diagram

Apoptotic cell 2disassembly Aaron Smith, Michael AF Parkes, Georgia K Atkin-Smith, Rochelle Tixeira, Ivan KH Poon 4.0.jpg

Conclusion

Dear readers, I've taken you down a long and somewhat circuitous path through the ups and downs of the immune system. This might seem dull, but the information is really important, because we all may be touched by an aberration in the immune system. In my own family we have rheumatoid arthritis, systemic lupus, pemphigus, diabetes, autoimmune encephalitis, COPD, psoriatic arthritis and more allergies than I can count. So I'm interested in how autoimmune diseases come about.

Information is power. When someone in my family goes to a doctor, I'd like to understand why a course of treatment is recommended--and to perhaps take part in a treatment plan. I hope this information might be helpful to you if you find yourself in a similar situation.
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Thank your for reading my blog and spending your valuable time with me
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Steem on!

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Some Sources Used in Writing This Blog

1.Mayo Clinic https://www.mayoclinic.org/diseases-conditions/lupus/symptoms-causes/syc-20365789
2;Biblio.com Flannery O'Connor https://www.biblio.com/flannery-oconnor/author/1780
3.NIH.gov https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565217/
4.ScienceLearn.org.nz https://www.sciencelearn.org.nz/resources/177-the-body-s-first-line-of-defence
5.Britannica.com: Mucous Membrane https://www.britannica.com/science/mucous-membrane
6.Alex Cotrell: Phagocytosis
7.Apellis.com https://www.apellis.com/focus-science.html
8.Merck Manual https://www.merckmanuals.com/home/immune-disorders/biology-of-the-immune-system/overview-of-the-immune-system
9.Science Direct https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/complement-membrane-attack-complex
10.MAC

steemstem #science #health #history #oc #medicine

5 years ago by agmoore2 (63)

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abigail-dantes (67) · 5 years ago

This has been an interesting read for me in many ways my dear friend. Above all, because of my very personal reasons to understand the workings of our immune system. See, I am allergic to every other thing on this planet. From household products to foods. I was very ill in my mid-20's, but not anymore ;) I have been strong and healthy for most of the past 13 years thanks to what you said: 'information is power' 😎

You have covered numerous topics here. And I always ask myself how you manage to do this without ever overwhelming your readers (?)! But I was mostly drawn to the 'Take out the trash' part, particularly when you highlighted chronic inflammation as a possible cause for autoimmune deficiencies, and linked this to specific conditions (e.g. SLE). As you might guess I have huge interest in, and have dedicated some time (for the past 3 years) to look into the links between inflammation and brain/mind disorders. It's incredibly revealing!

This is why I didn't think twice before downloading the recent study you pointed us to here on 'Autoimmune diseases & Psychotic disorders', in which the authors say (p.5):

Signs of a dysregulated immune system has also been found in mental illnesses and might play a role in the association found between the two.

This supports many, many other studies I have come across in the past. And, although such studies tend to place huge emphasis on the hereditary, biological side of these scenarios. Oftentimes painting a picture of little choice for patients, I see it as a glimpse of hope in how symptoms and suffering could be alleviated by life changes such as eating habits. Even more so when the role of the microbiome comes up over and over again. For example (p.7):

Psychological stress have been thought to influence composition of the microbiome and vice versa, as well as the microbiome's effect on peripheral inflammation.

As always, you have enlightened us with your thorough, well-researched work <3 Simply incredible and impressive!! :D

Much love to you always & forever my dear @agmoore2,
Your friend from across the ocean :*

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agmoore2 (63) · 5 years ago

Dear Abigail, I began this response earlier...had to leave on family business.

First of all, thank you for those kind words. I try when writing about medical topics to give people the sense that they should be partners in their medical care--not passive consumers.

This is something you apparently came to understand through experience. That is a terrible lesson to learn as a young woman. Overcoming serious illness gives you strength and insight I think. This may be one source of your great empathy. May your good health continue--for at another 50 years :)

As for allergies... I think you and I may have more in common than I suspected. Super-charged immune systems. But that's OK, because we have the resources to get what we need. And the good sense to avoid what can hurt us.

And I'm not likely to be overwhelming my readers with information..because I usually start from ignorance. I have to study the stuff inside out until it makes sense to me, before I can explain it to anyone else. No jargon in my pieces because I don't know any :))

I think epigenetics gives lie to all those who would blame heredity--for anything. The environment has such a profound effect on gene expression. Knowing this makes social policy--social equity-- all the more compelling. Heredity is a cop out, I think. Even something like Huntington's Disease, which is generally described as a genetically transmitted disorder, can be affected by lifestyle and environment.

Thank you for reading, and commenting on my long blog. I know you're busy, especially this time of year. So your feedback is much appreciated.

We are getting ready for Thanksgiving here, in the USA. I'm barely used to fall, and it seems winter is pressing upon us. Fall is my favorite season..best time for walking.

Hope you are well, peaceful, and not too pressed for time.

Love, from your good friend, in chilly New York,

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agmoore2 (63) · 5 years ago

Dear Abigail,
A postscript to my comment--my son just sent me a University of Birmingham article, which I thought you might find interesting (in light of your remarks about the relationship between inflammation and mental illness):

Link between inflammation and mental sluggishness shown in new study.

If you have ever visited an online lupus support groups, one of the most common complaints is 'brain fog'.

Hope you are having a great day, dear Abigail 😇

The Immune System: Your Best Friend, Your Worst Enemy

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