[ARTICLE] The Monkey Business of Laboratory Animals

in animal •  7 years ago  (edited)

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The Monkey Business of Laboratory Animals


Lab animals. We hardly give them a second thought when we hear about them. We know that they are being experimented with in labs across the world. We also know that they lead horrific lives and die heinous deaths. But, just as we give them a moment’s thought, we simply brush away those thoughts from our conscience. After all, there is nothing we can do about them, is it? Even those of us who consider ourselves morally strong and incorruptible, cannot find it in us to do something about the torture these unlucky souls undergo.


“Well, we need to test the drugs on something” we argue. “We can’t subject humans to testing before the drugs have passed animal tests. That would be wrong,” we try to reason. But, no matter what our stand is, in some corner of our mind, we know, we do admit that whatever is happening is extremely wrong. And the fact that we are beneficiaries of the system that propagates this carnival of torture only makes us feel nauseated. Perhaps, we might even wonder “whether the human civilization that is built on millions and millions of animals’ suffering is worth having?”

This black blotch on humanity deserves at least another fact-based discussion. Why?



Because even going by a conservative estimate, more than 110 million animals are used in lab testing across the world, every year. Some of them are allowed to die a slow death by asphyxiation, some are killed by water deprivation, and some are even left with their eyes open for days using clips, so that the labs can study the effects of their products which are regularly administered to their eyes. Other torture testing scenarios include neck-breaking, inflicting burns, psychological torture, testing of lethal doses of products, and many more worse forms of torture that only humans have the capacity to come up with. Many among us may point out “So what’s the big deal! We kill billions of animals just for food, when we can all go vegetarians and stop that massacre too. If we are comfortable with that, then why not with lab testing?”

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And you know what? That does make sense on some level. But, it is only half-truth. Yes, we are all comfortable with animal death. But, animal suffering? Now, that’s a whole another thing. Even slaughter houses are banned from torturing animals before killing them. So, you see, this is not about death. This is about suffering. Are we all morally comfortable being the source of so much animal suffering? This is a very difficult question. A question that we try to avoid by raising an alternate question – is there any other way?

Fine then, if there was any other way, would things be any different? Don’t be so confident of your answer. Here’s why.

Much of the animal testing in labs can be replaced by in-vitro testing. In-vitro means ‘in glass’. The name comes from the fact that in-vitro experiments are conducted in test tubes. Cultures of specific cells can be studied in labs to test their response to various chemicals, products, and conditions, quite similar to how animals are tested. In fact, there is a whole new industry selling cell-cultures for the sole purpose of testing. Human cells are artificially cultured on sheets, for instance, and sold for lab testing. These cell cultures make better test subjects than lab animals because the drugs or cosmetic products are being created for human use in most cases. And, it is not a matter of cost that is always forcing the labs to go for animal testing. Non-animal testing procedures are known to cost ten times lower. That’s right, lower! That’s impressive. This means that the labs do have a strong incentive to give up animal testing.

However, in many countries, it is simply a law to test their products on animals before testing them on humans. That being said, there are some cases, where medical technology is still not evolved enough to offer a better alternative to a living animal body. Complex biochemical structure of the living body offers huge challenges that cannot be replicated in labs. For instance the effect of drugs can be studied only when there is a circulatory system to deliver the drugs to target organs. Moreover, the complexity of biochemistry in the living body is such that a drug that is beneficial to one organ can be lethal to another. So, there is no alternative in some cases, other than to use lab animals for testing.

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Although this might mean that we have no other choice except to continue using lab animals for testing, there is another dark side to this industry. Animals make bad test subjects for human drugs. Surprised? But, it’s true. For instance, a sleeping pill caused severe congenital deformities in more than 10,000 children before it was withdrawn. The funny thing was that it passed animal testing with flying colors. Some of the most iconic drugs like aspirin were almost rejected because they failed during animal trials. The point is that the biochemistry, anatomy, physiology, and the very DNA structure of animals is different from that of humans. This difference is minute, but causes drastic changes in the body. So, drugs that are tested on animals often do not give the same results on humans. Now, just imagine how many potential cures for fatal diseases like leukemia, AIDS, heart strokes, and so on may have been rejected only because they didn’t pass animal tests. Let that sink in. That’s a scary thought, isn’t it?

So, let us come back to our original question – are we all morally comfortable being the source of so much animal suffering? Now we know that there are alternative options available before us. In most cases, the alternatives are even more effective than the animal testing methods. So, we can’t hide behind the façade of helplessness. We have no more excuses to save our self-proclaimed moral righteousness, while we simultaneously indulge in morally reprehensive acts. With that in mind, can we still continue to condone the repulsive and appalling torture of hundreds of millions of animals?

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Thanks!
Let me know your questions in the comments, and follow if you would like to see more unrelated to cryptos ♥

Photos by @Elmira G, @iTac, @Elly F and @Jad L


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I have thought about this point, **but you're right **, when you say it was quickly replaced by the next thought - ice-cream, laferrari or whatever robbed me of my attention

But now knowing there's an alternative, I can't help but think that the only reason they do this is to save an extra dime at the end of the day
...we are the most destructive/heartless species

Upvote, followed and resteemed

Exactly! I think we would go crazy tho if we didn't let ourselves think about ice-cream ;)

What is making me sad is the solutions we would come up with, if this was illegal. We would be forced to find different methods

Upvoted and Resteemed by the xx_Votes_Plus curation trail! Want more earnings? Follow @dropahead in Streemian: https://streemian.com/profile/curationtrail/trailing/396 and/or fund @dropahead with more STEEM POWER! Keep up the good work!

Thank you for sharing.
Some things that we definitely can do: avoid non medical products tested on animals. Apparently it forbidden in EU to test cosmetics on animals, and I'm sure for Germany.
Strive for healthier lifestyle- hopefully less medication (of course this is over generalization)
Also sadly a lot of everyday items are tested on animals (glue is one I've heard), so a bit more awareness with what we buy and if we really need those things. Also try to reuse what you can :)

Informative comment!
I will try to do my part :)

Sadly for us vegetarian didn't really work out. Haven't seen tofu or black beans yet and we got sick of what we did have(I'm currently in Skopje). But at least I try to lower meat amount and bought more containers instead of using foil and sandwich bags.(switched to Froch for almost everything) Also got a few handkerchiefs instead of tissues (my sinuses are a bit problematic), and kitchen cloths to use less paper towels. Stove top popcorn is so much better than microwave baggies. (And all of these things even save us money :) )
I hope little things can help overall.

Sad reality what humans will do for convenience. I think the best contrarian vote against it is the fact that cryptocurrencies are battling the established centralized systems of the world--and winning. One day the insanity will stop. For now, lots of animals have to take this abuse...Keep up the good work! thank you for the Steem!!

I really hope so :)

Quality read. Thank you for excellent content.! Following you.

great post like always
thank you

Thanks man! I really try :)

This is a very important topic that should be thought way more often as You said and also we should talk more about it as well.
I have became vegetarian for moral and ethical reasons and I try my best to be conscientious about this problems.
I admit I am still not doing very well but it is something I think really often and try to improve daily. Maybe I should be more vocal about it. Thank You for this amazing piece You put together. ❤ say no to animal cruelty

Indeed.
I think vegetarians do a good deed! For me, the most important part is that there is no suffering involved.

Thanks for coming by and leaving nice comments <3

We all need to do little by little

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hello, thank you for your act of kindness, im following you

Great post, I really like it. I am just follow you

You did not specify the definite alternatives to animal testing. Although i do not support animal cruelty, being a pharmacist i know that a lot goes into R&D before a drug hits the market it goes through at least three different phases of clinical trials where human subjects are used.
Besides if you read through medieval times of the practice of medicine you"ll not like what prisoners and captured people were used for in the name of advancing medical practice.
Would you rather a surgeon with loads of theoretical information as against practical experience take someone you know and care about in to a theater?

In-vitro is an alternative, as mentioned. Computer simulations, human patient simulator and volunteer humans (microdosages) are also good subsitutes.

Ok Maybe i was not detailed in my observation.
The limitations of invitro & computer simulations are

  1. the metabolic responses cannot be boxed. That is why even at second and third phases of clinical trials (where human subjects are used) there are still surprises and unexpected reactions and results. Some are good such that the clinical uses of the drug may be expanded but some are horrid that the drug is withdrawn. Case in point, the popular blue pill used for erectile dysfunction was originally being developed as a vasodilator for hypertension but alas the test subjects reported smiling benefits.
  2. There are drugs that in them selves are inert and need to be metabolized into their active form. They are called prodrugs and these constitute a significant portion of the drugs out there and they exclude drugs that are active in themselves and also have active metabolites. All of which can not be found out invitro but invivo.
  3. How do you determine doses and safety margins if invivo exposure and analysis do not take place? While there drugs that are safe at 20mg per Kg of body weight there are others that would most certainly result in death at 0.1mg per Kg of body weight. So how would know what dose is safe and what the limits are? How do you determine what doses would elicit the desire effects without invivo evaluation
  4. How do you determine frequency of dosing? Different drugs are metabolised and excreted via different pathways and within different time frames. Its via tests on living tissues and subjects (animals & subsequently humans) that how a drug should administered is determine ie subcutaneous or intramuscular injection as against oral or intravenous administration. How long would it take the body to eliminate the drug ie should be administered once daily, every six or twelve hours as the case maybe.
  5. You mentioned micro doses on human subjects how do you determine what doses can be considered as micro and what is mega taking my 3 point into consideration. Besides you could get very different results from different doses of the same drug where some organs were none responsive at lower doses, they could literally burnout at other doses.
  6. How do you determine safety in pregnancy & breast feeding invitro? I am sure testing safety in pregnancy to determine teratogenic effects is not an ideal route anyone would want to go.
  7. I think you should know that several life saving drugs like vaccines and insulin are extracts from animals and syntectic alternatives (especially for some types of vaccines) have not been developed.

In as much as i do not support animal cruelty, I also know that there is currently,as it were there are limitations in drug development and production without both animal testing and subsequently human testing.

  ·  7 years ago (edited)

I am aware of the limitations mentioned above, but I am unaware of what solutions we would be forced to invent if animal testing was criminalized.

Thanks for leaving an awesome comment!!

I think you could go far with more posts like this.... are you, by chance vegan or vegetarian?

Not at all. But I believe it's a good choice to make.