By a News Reporter-Staff News Editor at Cancer Weekly -- New research on Oncology - Cancer Risk is the subject of a report. According to news reporting originating in Zhejiang, People’s Republic of China, by NewsRx journalists, research stated, “The purpose of this study was to investigate the correlation between Interleukin 17 (IL-17) gene rs3748067 C>T polymorphism and gastric cancer risk through pooling the open published data. Case-control or cohort studies relevant to IL-17 gene rs3748067 C>T polymorphism and gastric cancer susceptibility were systematic searched for in the databases of CNKI, Pubmed, Medline, Embase and Web of science.”
The news reporters obtained a quote from the research from the Department of Gastroenterology, “The association between IL-17 gene rs3748067 C>T polymorphism and gastric cancer risk were expressed with an odds ratio(OR) and 95% confidence interval (95% CI). Statistical heterogeneity across the studies was evaluated by I2 test. Publication bias was evaluated by Begg’s funnel plot and Egger’s line regression test. Finally, seven case-control studies were included in our present study. Because of the statistical heterogeneity among the included studies for the aspects of dominant (TT+CT vs CC), recessive (TT vs CT+CC) and homozygous genetic model (TT vs CC), the data was pooled by random effect model. The pooled ORs were OR=0.99 (95% CI: 0.65-1.52), OR = 1.23 (95% CI: 0.73-2.06) and OR=1.14 (95% CI: 0.58-2.27) for dominant, recessive and homozygous genetic model respectively. The pooled data indicated no correlation between IL-17 gene rs3748067 C>T polymorphism and gastric cancer risk. Significant publication bias was found in the dominant genetic model (p <0.05), but not in recessive and homozygous genetic model (p >0.05). Based on the present evidence, there was no correlation between IL-17 gene rs3748067 C>T polymorphism and gastric cancer susceptibility in all genetic model.”
According to the news reporters, the research concluded: “However, for the small sample size, significant heterogeneity and publication bias, the conclusion should be further evaluated through well designed case-control or cohort studies.”
For more information on this research see: IL-17 gene rs3748067 C > T polymorphism and gastric cancer risk: A meta-analysis. Open Life Sciences , 2018;13(1):71-76. Open Life Sciences can be contacted at: De Gruyter Poland Sp Zoo, Bogumila Zuga 32A Str., 01-811 Warsaw, Poland.
Our news correspondents report that additional information may be obtained by contacting L. Zheng, Wenzhou Peoples Hosp, Dept. of Gastroenterol, Wenzhou 325000, Zhejiang, People’s Republic of China. Additional authors for this research include Y.C. Yu, L.Y. You and Y. Wang.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2018, NewsRx LLC
CITATION: (2018-05-01), New Findings from Department of Gastroenterology Describe Advances in Cancer Risk (IL-17 gene rs3748067 C > T polymorphism and gastric cancer risk: A meta-analysis), Cancer Weekly, 347, ISSN: 1532-4567, BUTTER® ID: 015572981
From the newsletter Cancer Weekly.
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