- Beedrill's English name was originally going to be spelled Beedril.
- Beedrill's effort value yield of 2 Attack and 1 Special Defense is unique.
- Beedrill can be seen as a parallel to Butterfree. Both of their unevolved stages evolve into their respective first evolutionary stages at level 7, which then evolve into their respective final forms at level 10. They both also go through metamorphosis-like evolution and share a base stat total of 395. Also, while Beedrill is a version exclusive of Black and Black 2, Butterfree is exclusive to White and White 2.
- In Pokémon Conquest, Beedrill is the only Pokémon that is featured without its evolutionary relatives.
- Mega Beedrill was designed by Hitoshi Ariga.
- Mega Beedrill has the highest Attack and Speed base stats of all Poison-type Pokémon. It also has the lowest Special Attack base stat of all Poison-type and Mega Evolved Pokémon, the lowest Defense of all Mega Evolved Pokémon, and the lowest single base stat of any Mega Evolved Pokémon.