I have noticed issues when sending Ethereum (ETH) to Bittrex when using Ledger Nano S.
The transaction fails and you lose your GAS transaction fee.
To resolve the issue click on "Advanced Mode" on the ledger nano transaction scren and change the GAS limit to 40000 and change the Wei price from 6000000000 to 12000000000
Once I did this the transaction worked.
I hope that helps
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