Study explores therapeutic potential of exploiting autophagy cascade against COVID-19

in hive-192465 •  3 years ago 

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Autophagy is [a] cellular catabolic mechanism that arbitrates the degradation of undesirable protein aggregates and damaged organelles and recycles the degraded components.

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Under normal conditions, autophagy will fight against infections and viruses by breaking down and recycling unwanted proteins (as seen in the top image). It has been speculated that COVID-19 and the previous Sars virus hijack the autophagy mechanism (image below).

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In addition, based on the current knowledge available (Gassen et al., 2020; Singh et al., 2020), we strongly believe autophagy inducers (such as Sirolimus, Everolimus, Trehalose and Valinomycin) hold great promise as an alternative therapeutic strategy.

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Here is another way to induce autophagy without taking any special drugs.

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