We have already written a full article about leptin. This article is about leptin resistance. Leptin resistance is common in obesity and does not suppress appetite. Scientists are studying how leptin sensitivity affects weight loss and inflammation, but can you actually reverse leptin resistance? Read on to find out what the latest research suggests.
What is Leptin Resistance?
Obese people have high levels of leptin, which means there is a strong link between leptin and obesity. But is it too simple? To reverse, leptin is produced by fat cells in the body. It is called the “saturation hormone, obesity hormone, or fat hormone that leads to weight loss and finally the“ hunger hormone. Preliminary studies have highlighted the approximate effects of leptin on weight loss, but other studies have found that leptin is not the weight loss pill everyone is looking for.
What Are The Mechanisms of Leptin Resistance?
Numerous mechanisms have been proposed to explain Leptin Resistance Symptoms, including leptin impairment and leptin signaling problems. Limited studies show that the amount of cerebrospinal fluid increases slightly in obese people with very high levels of leptin. Thus, scientists believe that leptin may not enter the brain and maybe part of the problem. However, this theory has not yet been confirmed.
Sleep & Circadian Cues
Circadian rhythm disturbances were associated with leptin resistance and obesity in animals. Most of the existing human research focuses on combinations, so it is not possible to determine whether circadian problems may be resistant to leptin. However, maintaining a healthy circadian rhythm is known to support mental and metabolic health. For example, one study found that night worker who was awake, active, and eating at night were at greater risk for obesity and metabolic disorders.
Avoid Eating at Night
Some studies show that during the natural history of daily mammals, we ate about 12 hours during the day and fasted 12 hours at night. According to circadian index theory, it has also been hypothesized that eating at the wrong time can contribute to circadian desynchronization and weight gain.
Avoiding Overeating
According to animal studies, chronic high levels of leptin can eventually lead to leptin resistance to stay in homeostasis. Researchers have found that excessive consumption can lead to long-term chronic high levels of leptin, which can lead to leptin resistance. At this stage, people usually find it difficult to lose weight because several metabolic pathways are unbalanced.
Reducing Refined Sugars
Consuming too much sugar and saturated fat in the Western normal diet is a decisive factor in worrying about obesity. Unhealthy fast food diets cause an inflammatory reaction in the hypothalamus in animals, which contributes to the development of resistance to brain leptins and obesity.
Increasing Healthy Proteins
In a small study of 19 people, an increase in dietary protein from caloric intake to constant carbohydrate intake by 15% to 30% resulted in a steady decrease in caloric intake. Participants also lost weight. The authors speculate that this may have been mediated due to hypersensitivity to intracerebral leptin. They believe that the appetite-reducing effect of protein contributes to weight loss due to low-carbohydrate diets. In the postmenopausal women test, a low-carbohydrate diet that lowers leptin levels and increases adiponectin resulted in