By a News Reporter-Staff News Editor at Chemicals & Chemistry -- Research findings on Chemical Research are discussed in a new report. According to news reporting originating from Fuzhou, People’s Republic of China, by VerticalNews correspondents, research stated, “UCS1025A is a fungal polyketide/alkaloid that displays strong inhibition of telomerase. The structures of UCS1025A and related natural products are featured by a tricyclic furopyrrolizidine connected to a trans-decalin fragment.”
Financial supporters for this research include Japan Society for the Promotion of Science, National Institute of General Medical Sciences.
Our news editors obtained a quote from the research from Fujian Normal University, “We mined the genome of a thermophilic fungus and activated the ucs gene cluster to produce UCS1025A at a high titer. Genetic and biochemical analysis revealed a PKS-NRPS assembly line that activates 2S,3S-methylproline derived from l-isoleucine, followed by Knoevenagel condensation to construct the pyrrolizidine moiety. Oxidation of the 3S-methyl group to a carboxylate leads to an oxa-Michael cyclization and furnishes the furopyrrolizidine.”
According to the news editors, the research concluded: “Our work reveals a new strategy used by nature to construct heterocyclic alkaloid-like ring systems using assembly line logic.”
For more information on this research see: Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids. Journal of the American Chemical Society , 2018;():. (American Chemical Society - www.acs.org; Journal of the American Chemical Society - http://www.pubs.acs.org/journal/jacsat)
The news editors report that additional information may be obtained by contacting L. Li, Engineering Research Center of Industrial Microbiology (Ministry of Education) and College of Life Sciences, Fujian Normal University, Fuzhou 350117, People’s Republic of China. Additional authors for this research include M.C. Tang, S. Tang, S. Gao, S. Soliman, L. Hang, W. Xu, T. Ye, K. Watanabe and Y. Tang.
The direct object identifier (DOI) for that additional information is: https://doi.org/10.1021/jacs.8b00056. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
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CITATION: (2018-02-23), Researchers at Fujian Normal University Target Chemical Research (Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids), Chemicals & Chemistry, 2773, ISSN: 1944-1525, BUTTER® ID: 015197962
From the newsletter Chemicals & Chemistry.
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