Oral bacteria in the gut could drive immune cell induction and inflammatory bowel disease

By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- On average, we humans ingest 1.5 liters of saliva containing bacteria every day. Could this possibly have harmful effects on our health?

According to Professor Masahira Hattori of Waseda University, the answer is yes. “We noticed that oral microbes are relatively enriched in gut microbiomes of patients with several diseases such as inflammatory bowel disease (IBD), HIV infection, and colon cancer compared with healthy individuals.” However, the causal role of oral bacteria in the intestine has remained unclear.

Professor Hattori and Professor Kenya Honda of Keio University School of Medicine led research to investigate the relationship between salivary microbes and IBD, and they found that when the bacterium Klebsiella pneumoniae colonizes in an intestine out of microbial balance, immune cells called T helper 1 (TH1) become overactive in the gut, resulting in intestinal inflammation …

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(2017-12-02), Oral bacteria in the gut could drive immune cell induction and inflammatory bowel disease, Obesity, Fitness & Wellness Week, 2191, ISSN: 1532-4664, BUTTER® ID: 014745533