This error belongs to the error 15xxx series of error codes. Out of the multiple causes behind this error, the most common technical error is an improper Internet Explorer configuration. Also, an out-to-date digital signature certificate could also provoke QuickBooks error 15221.
Fix 1: Go for Clean Installation of QuickBooks
Fix 2: Add Intuit in Trusted Sites list
Fix 3: Update QuickBooks
Fix 4: Install a digital signature certificate
Fix 5: Turn off Firewall
As we come to a close, we hope that users find the different solutions in this blog useful to fix QuickBooks Error 15221. Users can simply give us a call at the helpline 1 800 761 1787.