There's some correlation, but I originally came over to DFS from being a successful year long player and struggled for a few months. I played 10-20 leagues a year, probably had around a 10% ROI, but DFS was different and I lost a couple thousand my first foray in. But with a poker and season long background it doesn't take all that long to figure out, probably took me 6 weeks of NFL and I started winning in NBA right away.
I would say play mostly 50/50s, you'll get bumhunted at HU, and the 50/50s probably have more bad players percentage wise for someone new. And play lots of beginner contests if you are just signing up on a site.