AFAIK, Warframe isn't particularly based on any one mythology; a lot of the names come from Greek mythology, and there's definitely a little bit of Greek bias (perhaps because Greek and Roman myth is pretty common) in the imagery of the storylines and the Orokin, but there's a pretty heavy emphasis on having the whole thing flow out of this framework of mythology that makes the story truly epic.

It's a good game. I don't play it all that much, even with that said, but I definitely think that Warframe is one of those games that both treats players right and does a good job of being a fun game (they're not unrelated, mind you, but there are games that have the best intentions and fall flat).