our professor always was mad when we had to use deuterated DCM or toluene-D8. But sometimes theres no other way. nmr spectra of badly solved molecules are useless
RE: solvent
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solvent
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Definitely! Usually the problem is solubility so I have to use alternatives.
d6-benzene was slightly cheaper than I expected ~ but to do benzylic proton exchange to deuterium should be much more challenging so the price is higher (?)
(I expect d6-benzene was made by hydrogenation and dehydrogenation with D2 gas on some catalyst)
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When I remember correcly for benzene it is possible to just stir or boil(?) it with D2SO4 for proton exchange. A colleague tried this way for xylene but just ended with a messy black slime...
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oh I didnt expect D2SO4 is strong enough!!!
Haha black slime, so sad ~
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