Today in high impact science Research News we discuss a publication from Nature titled "Ketamine blocks bursting in the lateral habenula to rapidly relieve depression." Where researchers from Zhejiang University in China have been studying the mechanism behind which Ketamine has its anti-depressive effects.
I am sure many of you know the name of the drug Ketamine, or Special K as it might be called in a "street pharmaceutical" format. It's a fairly commonly used anesthetic in surgeries, as it gives people a trance like state, where the sensation of pain is reduced and also has the convenient effect of causing memory loss. [2], which is perfect for surgery. Its use as a street drug stems from the fact that it also can induce hallucinations, but it also has other effects.
For instance it is a very very fast acting anti depressant compound. With a single dose in as little as 30 minutes it can result in a long lasting antidepressant in people. [3] This has been hypothesized in the past to revolve around ketamine's interaction with the N-methyl-D-aspartate receptor (NMDA Receptor).
NMDA Receptor
The NMDA receptor is actually a glutamate (amino acid) binding receptor, that gets its name because in addition to binding glutamate it also binds very specifically to the compound N-methyl-D-aspartate. It's commonly found in our bodies and is what is known as an excitotoxin, in that it destroys nerve cells, by over exciting them.
Ketamine however, is an antagonist of this receptor, in this case it stops the NMDA receptor from firing.
Mechanism of Action of Ketamine
What the researchers identified is that the blocking of the NMDA receptor by ketamine in a particular section of the brain called the lateral habenula resulted in antidepressive effects in both mouse and rat models.
The researchers explored this phenomenon from a variety of angles, finding increased neuronal firing ("bursting") in the lateral habenula region in depressed brains. Which were not found in non-depressed brains. The researchers also observed that these "bursting" patterns observed could be removed by the addition of an "anti-depressant" concentrations of the Ketamine. An interesting observation but they were not yet satisfied.
They explored further to determine the mechanistic cause of the observed change in neuron firing patterns. They found through varying the concentrations of ketamine used, that the bursting activity was due to the actions of the NMDA receptors, and also found that the alleviation of bursting could be re-instituted by providing high concentrations of the NMDA receptors normal substrate (NMDA itself).
Impact
The authors have convincingly illustrated that the relationship between neuronal burst firing in the lateral habenula and a depression-like state is strong. They have also shown that the very rapid, anti-depression activities of Ketamine are related to the compounds ability to alleviate that burst firing state. They identified the mechanism by which this happens (blocking the NMDA Receptor) and have opened up a whole new target for the development of future fast acting anti-depression medications, hopefully without the other antithetic like properties of ketamine.
Sources
- https://www.nature.com/articles/nature25509
- https://www.drugs.com/pro/ketamine-injection.html
- https://www.ncbi.nlm.nih.gov/pubmed/10686270
Image Sources
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I feel like a lot of drugs can cure depression but is it actually good as long term on health ?
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Nothing cures depression, its just treated. Good long term on health? Depends on the context in which a drug is used.
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Ketamine can have profound long term effects from single intervention (without behavioral therapy used in concert with it), which do seem to fade over weeks.
I attended a 'Grand Round' at BIDMC a few years ago about ketamine and depression, where the researchers stated that their preliminary data suggested that ketamine had far better long term effects on treatment-resistant depression than many of the commonly employed techniques!
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The Ketamine produces psychological dependence and long-term physical dependence.
It also produces short-term tolerance can produce serious and unpredictable effects and eventually produces irreversible brain effects.
It is important to take into account that there are several types of depression, which are: major depression, dysthymia, bipolar disorder and post-partum depression.
Depending on the problem, treatment for depression may be necessary in two ways: pharmacological and psychotherapy.
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HAH never imagined my university would be featured in one of your articles!!! But yes, Zhejiang University is known all over china for the HUGE amount of papers that gets published every year!!
I read about this research in one of the newsletters I think. The key would be to find a way to specifically target the lateral habenula (I know this is much easier said than done), but a widespread blockade of NMDA to treat depression might have unforeseeable side effects, given glutamate is the major excitatory neurotransmitter of the CNS. But blockade of NMDA receptors is already a known mechanism to prevent progression of neurodegenerative diseases, Who knows if this new line of research will link some underlying neurodegenerative process with depression.
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Clearly they are doing some really impactful science there!
Well that is the goal, now that one knows what to target, ways to specifically get there can be devised.
What if only brief blockade is sufficient to treat depression for an extended period of time? Sure long term inhibition would affect a variety of other pathways, but perhaps that isnt necessary?
Now there is where things could get interesting.
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Would be the ideal scenario, but so far I don't think there is any medication available that is able to do this for depression, or any other medication that I know of working on CNS neurotransmitter in this fashion.
Temporary inhibition having "significantly" long term action is yet alien, but definitely something that deserves attention!! Would definitely save the patients of so many unnecessary side effects, not to mention long term, potentially permanent damage to the CNS and even the risk of developing tolerance or dependence. Yes, this would definitely help with the issue of tolerance or dependence developing with so many of the CNS drugs.
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I agree... I've read a book about depression (Depression and its Treament, just don't recall the author) one of the best thing the we could give to those people have depression is LOVE and understanding.
I don't have a medical background but I 've read those medicines for people has depression only alleviate their suffering .
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👍👍😎
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Hey, @justtryme90. This is a great post! There are so many new applications being seen for ketamine recently. In the compounding pharmacy that I used to work at, we filled prescriptions for a plethora of different reasons. I have read and heard a lot about the usefulness for depression in the medical community, but there are many other reasons to be excited about ketamine's partial antagonistic effects!
I talk a bit about ketamine for treatment of PTSD in this post if you are interested!
I will certainly be following you and looking out for more posts like this! Cheers :)
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Thats a nice post, you should consider including the #steemstem tag so the curators might not miss subsequent ones.
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Yeah, I only more recently became aware of the steemstem project. I am so impressed by it, and want to thank you so much for your work, @justtryme90. You have helped create an amazing ecosystem of informative and enjoyable content!!!
I just wrote a more molecular neuroscience dense article using the #steemstem tag this morning: Molecules to Mental States: Psychological Stress and Cell Death. Thanks so much again!
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Also, a typo that I noticed: "Ketamine however, is an agonist of this receptor, in this case it stops the NMDA receptor from firing."
It is actually a selective antagonist, which as you state reduces the excitability of the neuron.
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It's always nice to know they're looking into how these things actually work, may see more targeted drugs in the future come from this research, although there aren't that many negative side-effects it seems from paired ketamine/therapy sessions.
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But what does cinnamon toast crunch cure?
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Whoops! Thanks for pointing that out. :)
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@justtryme90 Thank you. You have supported my material. This is the biggest payout I will receive on steemit. It's nice that there is appreciated classical music. I do not need anything, you can even not respond to a message. Just zashchel say thank you.
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People who go through strong depressions can take their lives and perhaps other people's lives, this drug would help to reduce the number of deaths by people who are upset.
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Wow!
This is so so amazing
I've got no regrets following you I'm a botanist.
And I think following you I will get to be exposed more.
Hope such essential drug won't be too expensive as well?
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This is not an essential drug, but it does have potential uses outside of anesthesia.
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So much to learn not just in chemistry but in life as well.
Many who are suffering with depression in my country, Philippines, are taken by death. And in some point of life, there are still many out there, refering to other countries, are in the same tract as us.
I don't know much 'bout science, which I wish I would, so I'm having a hard time understanding every scientific word :(
But then, I Still find this article truly helpful and knowledgeable in every way.
I started following you to start my journey in understanding science even more. :)
@smafey
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Great post @justtryme90.. thanks for sharing
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Doubt it. People are afraid of using their brains.
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yes, but if they start using their brain they can do anything @justtryme90
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What if we charge per minute? That could add incentive!
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Charge people to use their own brains?
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It was intended to come off as an overt joke, but I am certainly not a comedian!
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It is so informative post. Great Invention. Thanks for sharing
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Thanks
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awasome and invention post...sometimes everybody effect depression...so depression remove drug by Ketamine.very well post......
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Thank you
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Es bueno saberlo
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Gracias
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Sounds great, however, do they mention something in the paper about physical or mental addiction to ketamine?
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This was a mechanistic paper, it wasn't looking at the effects on a person.
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Keeping the side effects aside, Ketamine is doing great job in treatment resistant depression.
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Indeed, mechanistic understanding such as that revealed in this article will be useful going forward to better understanding depression causes as well.
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When rats take special K they're happy, but when I take it I apparently need to "stop making a scene" and "put my pants back on." Ridiculous.
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Something about put your hands behind your back, anything you say or do can be used against you in a court of law.
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You gave an important news I liked your post. I'm looking forward to your next post
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Great!!!!
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Qt well explained and informative post
@justtryme90
Have a look on my work too if u dont mind and comment is appreciated
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Long used as an anaesthetic and analgesic, most people familiar with ketamine know of it for this purpose. Others know it as a party drug that can give users an out-of-body experience, leaving them completely disconnected from reality. Less well known is its growing off-label use in the USA for depression, in many cases when other options have been exhausted.
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Yep, and up until this study, nobody had a clue how it actually worked in that regard.
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This is some pretty amazing research work I must say. Indeed depression is a small but mighty evil terrorising a terrifying number and percentage of the world's population from time to time and on a daily basis too. So articles like this actually do go a long way. Thanks for sharing this jtm :)
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Thanks for reading.
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Special K sounds interesting; I thought I know many types of street drugs, but this one is my first time of hearing it. Some of these street "pharmacists" sure know how to get their high virtually off any drug that has other uses in the world.
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Well that's a necessity for selling drugs illegally :)
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True :)
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Very educative post. Thanks for sharing.
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Thanks
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Especially when waking up from it, I can even see it happen in animals, they get afraid of things that aren't there at all!
Every time people hear I'm a vet student they either ask for ketamine or for equiboost (horse testosterone), didn't know the street name was special K, I guess @justtryme90 has some street knowledge!
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You pick up on a few things when people joke about stuff when working for Pharma.
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Very interested post, thanks alot for your upvote me..!.
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great post......nice one.......
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Your correction is almost good sir.I like your post.Thanks for sharing.
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Are you telling me that the box of Special K cereal in my cupboard wasn't actually cereal and thats why my parents told me not to "eat" it?
Just kidding, however I should add: "post well written" etc etc, all the usual spam. Anyways onto the meat of my comment, so ketamine (commonly referred to as a horse tranquilizer) has anti-depressive properties to it? So it has 3 uses: hallucinate, be happy, and forget the pain of a surgery (or life in the case for depressed patients)
Basically every drug that can be used as an antidepressent can be easily sold on the street and make yo tons of money (though I mean kids at my high school got caught with dollar store spices thinking it was pot :/ )
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Lol. A brilliant future ahead of that one.
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beautiful and awakening post....will be following u for more scientific revelations now
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Thank you, that is very kind.
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That is a good post... Thank you for share it...
You are the best.. Good luck..
May God always bless you 😃😃😃😃😃
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Your post is very good and perfect. thank you for accepting me.
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The simple life we are living today has been possible only due to science. Your writing is very good and will help you to know more about our lives. Thank you.
And because of the steemit we get all these news more quickly.
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Wow, this is quite groundbreaking actually! As a nurse we often use ketamine for sedating patients, just before they get spinal anasthesia. Also of course, growing up in Holland ketamine is a well known street drug in the clubbing life.
Cool to know this is also a new discovered feature. Definitely spamming my co workers and bosses with this type of info to dig deeper into this topic
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There is a variety of literature out there describing its effeciveness against depression (especially depression which does not respond to other treatments). Unfortunately ketamine is still not a good option because of the other side effects.
What makes this literature so impactful is the identification of the mechanism by which Ketamine is having this antidepressive effect. Opening the door for the development of new compounds which will work this same way, but with out the other effects of ketamine.
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That would be really revolutionary if that type of development could actually be achieved!
Modern medicine is beautiful sometimes, just the money involved in it is often such a disaster
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Nice @justtryme90 👍👍👍👍
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wow, nice bro!
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Fantastic post, very useful.
Thank you so much..!.
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I would never have thought a drug like this for use in depression, but it makes sense. Shame it's not further along, I know so many that could benefit from it. Thank you for bringing this to light.
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Informative post thank you for sharing @justtryme90
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Great work .
Proudly chemist
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I just know ketamine. a very useful post I will definitely follow you
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Interesting post!
I don't write about science because i don't feel skilled enough on any specific field but science and science fiction are my passions... also traveling :)
gonna follow you!
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We must each follow our interests in blogging, if science fiction is your passion then keep driving there :)
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I haven't done any post about science or science fiction yet... I'm not sure how to engage a post on those issues... I may try when I run out of traveling stories... :)
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Its not easy to get an engaging post with science material. I am still trying to figure my way around it and I've been learning for almost 2 years now... ugh.
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seemt to me your doing a pretty good job!
I hope to get somewhere close to that with my kind of posts...
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Good post @justtryme90 . For healthy
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amazing...the medical science is growing up to all class of people. i think this research is very effective for us. thanks for your sharing to us.i will waiting for your next informative post.
@upvote & @resteem done
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dear @justtryme90
we know SSRI has more anti-depressant effect than TCA.but is ketamine best than SSRI??
good research..@upvote & @resteem done
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It's different then SSRI, works seemingly in different situations, and is definitely faster in action. This is not a case of better/worse but orthogonal.
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sir..is ketamine has local anaesthetic effect?
as a medical student..i read that also called"street anaesthesia".is it true??
sir ewe are proud to get you..thanks for sharing.
@upvote & @resteem done
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No, it's a general anesthetic. Well its mis-used as a recreational drug due to its ability to induce hallucinations. So yes, street anesthesia would be a slang term for that I suppose.
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yaahh..i understand.thanks sir
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hai master, thanks for the help. we can greet each other.
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Nice post @justtryme90 i love biology science.
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This post very interesting for me ..
Thank my freind ..Im resteem this post ..
You are smart
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Thank for your vote my freind ...
I do not suspect.
You are the best
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Dear @justtryme90, I am very grateful for you and thank you for visiting my blog @acehnature.
My email : [email protected]
Thank for you and thank for all. 😊😊😊.
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I really like your post @justtryme90
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a post full of information thanks I like @justtryme90
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@justtryme90 I have read the post with interest, about Ketamine, certainly modern life and poor nutrition lead people to have extreme situations and the right medication can alleviate these problems. I have already activated in the Discord de steemstem, I will be awaiting your news and a possible contribution from me. Best regards
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Thanks. This is facinating. You are not only into physics. Does Ketamine work by activating the N-methyl-D-aspartate receptor? In that case there would be an influx of feel good signals.
I like the way you write. It has been 20 years since I have been in molecular but I would like to get back on the band wagon.
When I do a post on health I will share on your discord. You are one cool Steemian. I'm honored. @justtryme90
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Its an inhibitor.
Never a better time then now :)
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Thanks. Great inspiration. I will get my get my molecular but in gear by the end of this week.
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Things that cure depression...
Dancing
Smiling
Laughing
Walks thru nature
Friends who uplift you
Music that speaks to you
Having a positive outlook
Working out
Martial arts
Exploring spirituality
A healthy diet
Mushrooms not acid
And/or taking the time to consider what you are ingesting. Verbally, mentally, emotionally, physically and spiritually.
These variables dictate your entire state, and when one of them is out of sync, everything is.
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You got a 4.76% upvote from @brupvoter courtesy of @jmehta!
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I would never go near Ketamine, Cannabis FTW...
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Okay
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Would you not agree that Cannabis would be far superior for treating depression, if you use Ketamine; not feeling depression would be the least of your worries because you won't be able to feel your fuckin face lol...
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No, I would definitely not agree. You also missed the entire point of this blog post, as well as the article.
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I do not speak English because I apologize in advance for possible mistakes in the construction of proposals. I do not have a doctor's diploma for a second education special psychologist. This is work with people with disabilities. We are not doctors, but when studying we studied genetics and pharmaceutics, certainly not as profoundly as physicians.
Moreover, I was very interested in medicine in antiquity. Some people underestimate it. Doctors of the Middle Ages are savages. Of course medicine has made a breakthrough. But in the Middle Ages there were apothecary gardens. From the bark of the willow, you can weld aspirin. A good sedative is cooked from the root of valerian.
Chemicals in the treatment of the nervous system are quite dangerous. First of all because of the pharmaceutical companies. Often, in pursuit of profit, they do not undergo a complete test. It is not very clear how this can tell on the health of a person or his children after tens of years.
Maybe I will not say the most popular idea, but money is often killed. More precisely, the pursuit of profit of large companies.
Therefore, it is best to use the drugs checked by centuries. Deep depression is also helped not by medical means.
If a person is ready to commit an act of suicide, you can use ordinary products. To force to drink a glass of water where there is a lot of red and black pepper, there is garlic and onions. With a burn of the mucous membrane of the mouth, a person begins to resolve the issue of discomfort.
He does not care about stupid and dangerous thoughts.
Although with a false value system, this may seem cruel. The question is what can be done to save the person and his personality.
Once again I apologize if my words and suggestions are very incomprehensible. I do not speak the language.
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No, thats stupid. It is best to use drugs checked by advanced scientific analysis.
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Why use drugs in treating depression? I understand when it comes to medical intervention and surgery. I understand, when there is a treatment of a mentally ill person, then psychiatric drugs are needed. Usual depression and drugs. You can kill a fly from a cannon, but too strong a weapon for a fly. You can hammer nails with a microscope, but why?
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Because depression is not sadness. It is often caused by a physical problem in the brain. Enzymes gone wrong.
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I think I do not speak enough language to continue the argument. I do not understand whether you are serious or joking.
If this is not a joke you will have very big problems. Not you personally from a whole people. This is your choice. But this is a choice of suicide.
One question, why not one country in the world is not treating depression with drugs?
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I am 100% serious.
You don't have one clue what you are talking about.
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Pharmaceutical addiction is provoked by corporations. Although it is more difficult to continue dialogue. You do not quite understand me, I do not understand you either.
Pharmaceutical addiction.
The pharmaceutical anesthesia of society has acquired a catastrophic scale. In the USA, between 1985 and 2010, the use of antidepressants by people aged 18-44 years increased by 400%. In 1998, 11.2 million Americans took antidepressants, in 2010 it was already 23.3 million from 2005 to 2008. 11% of children aged 12 years used pharmaceutical drugs.
I studied the question, but do not have the knowledge of the language to continue the dialogue at the proper level.
I do not agree with your opinion. For your right to speak my mind, I am ready to fight.
Therefore, we finish our argument. I can not give exact sentences I do not know the language. You do not always understand me. I do not always understand you.
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Thank you for proving my point. Complete rubbish.
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Oh Jesus. Memory loss = no pain? This is like a horror movie scenario to me. Torture free-for-all, as long as we wipe out the memory at the end, it didn't happen.
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Do you want to remember being cut open during a surgery? I don't.
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Informative post, very very good information.
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I think eating healthier might help some people. The government needs to stop subsidizing unhealthy foods! The Feds help kill way more Americans than the terrorists.
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The responsibility falls on voters, to remove politicians who don't want to change things.
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many many thanks just for your vote
am very grateful to you
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I think that in a short time this drug will be very effective and very helpful, the main problem that I find is that in the long run it will create an addiction to it. Great post by the way
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It will! Which is why people need to use this mechanistic information to make different molecules with out the draw backs of ketamine.
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Nice to meet you
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Is it the one world in need
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It is an interesting post about Ketamine. I am glad that through your post I discovered this project @steemstem, it seems very interesting. Have a great weekend!
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Loved
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Great post.
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Thanks bro for upvote me
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Great review. I think Chinese medicine will be more useful if Western world tries to understand it. Sounds like there's lots of new things to learn.
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This is not Chinese medicine. It is just work done by a Chinese research group. "Chinese medicine" is bullshit. Do you know what we call "Chinese medicine" that works? Medicine.
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lol. I'm sorry it's my bad, I didn't notice it. I thought it's Chinese medicine. Now it all makes sense. Thank you.
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Hi @justtryme90,
"Do you know what we call "Chinese medicine" that works? Medicine." - :D :D :D
I've actually published an article on a similar topic: "One of the biggest lies of the modern society - “natural is a good” two months ago. Here's an extract from it:
As the society is progressing, more and more products contain artificial elements that we don’t understand. Furthermore, we know that many of these artificial elements are harmful to our health. This leads to “returning to nature” trend, which means that people are increasingly opting out for natural products (and "Chinese medicine" sounds natural).
But, in many cases, artificial elements are simply way better than the natural ones. For example, sure, you can clean your house with vinegar, but it’ll be much easier and effective to do it with a CIF cream. The same goes for our hygiene. Sure, you can find and purchase (for a relatively high price) a 100% natural soap, toothpaste, shampoo, deodorant, but I doubt that they will do the same (or nearly the same) job as products that combine safe artificial elements with some of the most useful natural ingredients.
The above examples are nothing when compared to medicine. Nowadays, many people think “I don’t like medicines, who knows what’s in there” and choose to use just natural “medicines”. Heeeeello there, medicine is, along with ICT, one of the sciences that have made the highest progress in the last 100 years! Of course, If you have a minor cold, you can just drink a tea with lemon and honey, get warm, and rest, but if you are seriously ill, you need to see a doctor and use an artificial medicine, as for a serious illness that is the best thing to do.
The similar thing is happening with the natural beauty trend. Ever since we evolved from monkeys (or got created by someone/something, choose whatever you like), we tried to make ourselves more beautiful. Why? Because it’s good to be pretty, as it is good to be healthy, fit, smart, educated, funny, rich, etc. There’s nothing wrong with that. Thus, it is normal and desirable that girls dye their hair if they are not happy with their natural color, that they use some makeup, that they dress well, that they depilate their legs etc. If we want to philosophize, it’s not even possible not to use beauty products at all, since all of our closing isn't (already for millenniums) just made to make us warm and comfortable, but it’s also tailored, dyed, and decorated to make us pretty. If we would want to be 100% naturally pretty, we would have to go around town naked!
Cheers,
@lifenbeauty
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I think best medicine is morale though. If we look at The NNT website, we see most medicines are not useful like they taught us in medicine school. But I think preventive medicine is the most important. Chinese medicine or traditional medicine is useless as well. In drugs there are only helpful ingredients, instead of lots of thing like in Chinese medicine.
My idea about it is preventive medicine will be big deal for modern medicine in near future. What do you guys think about it?
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I agree with you that preventive medicine is very important.
It could be compared to positive psychology, which helps us be mindful and enjoy our lives instead of treating the consequences of bad thinking patterns.
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extraordinary unique and different post thanks @justtryme90
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great news
medical science are introducing day by day new things
now a days depression is main issue , people take stress and many diseases due to stress
Thanks for share this information
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Between 13 and 14 million Americans suffer depression each year. Of those who are trying to be treated, 30-40% will not be able to completely get rid of the disease with the help of standard antidepressants. Because of this, millions of people are at increased risk of alcohol abuse, drug addiction, and suicide; they are more likely to go to hospitals. Today, scientists pin high hopes on the drug for anesthesia ketamine, which could help such patients. Ketamine has a reputation for being a party drug that has a hallucinogenic effect. But in the United States there are many clinics that use ketamine to treat patients with depression, which did not help the standard drugs. Ketamine is also used in emergency rooms to save the lives of patients with suicidal thoughts. "The benefit of its application is quite impressive, and the data on the effectiveness of solid" - says psychiatrist Dr. Kyle Lapidus (Kyle Lapidus). He works as a teacher of psychiatry and neuroscience at the University of stony brook. Professor Lapidus saw a lot of research, which gave good results, but the number of participants in such works was limited. Ketamine acts quickly, often within a few hours, so the health workers who give it to patients in normal therapeutic doses, noted that most people he has a weak and transient effect. The drug has not been studied for long-term efficacy and safety in depression. The FDA has not approved ketamine for the treatment of depressive States "the Pace of research in this area is too slow for people who suffer and require other treatment," says Lapidus. The doctor claims that in America is not so unusual case when the doctor prescribes medicine on the indications which are not specified in the instruction. In the case of ketamine, small studies, including his own, confirm that the drug helps. Sam Lapidus, head of the "ketaminebuy clinic" in Manhattan, called US Ketamine. Soon, the doctor plans to open a second clinic on long island.
Experts do not know exactly how ketamine works in depressive conditions, but they know that the mechanism of its action is fundamentally different from the traditionally used antidepressants, such as Prozac or zoloft. This may explain why people who do not respond with approved medications respond well to ketamine. "This is a new, awesome method," says another psychiatrist, Dr. Alan Manevitz. Dr. Manewitz specializes in the treatment of persistent depression at Lenox hill Hospital in new York. According to him, it is amazing to be able to go to work immediately after treatment, than ketamine is different from other antidepressants, which give relief in weeks or even months. "The rapid improvement in well – being and mood - that's why ketamine looks promising," says Manevitz. The doctor warns that despite the success of ketamine, it is impossible to consider only one method of treatment of depression. It is necessary to take into account all aspects of a particular case, from biological and psychological characteristics to the social environment. "Ketamine is not a miracle. He can instantly improve his condition in depression, but he does not solve all the problems. To treat psychiatric patients is difficult – you have to approach treatment holistically," warns Manevitz. For people who are thinking about suicide, this medicine can really be a lifeline. Recent studies have shown that a single dose of ketamine repeatedly reduces the risk of suicidal thoughts in patients with depression. It is also unknown whether long ketamine acts in depression – a few days or a few weeks. But this time window may be critical, it is therefore necessary to conduct further research. "We need effective treatment for suicide attempts. Ketamine can be a bridge for some that helps to get back from suicidal thoughts to life. We give ketamine, which is valid for 3 days or so, and during this time we use other methods of exposure, other drugs, psychotherapy," explains Dr. Elizabeth Ballard (Elizabeth Ballard), a researcher of depression. Dr. bellard is a research fellow at the U.S. national Institute of mental health. In August 2014, she published a study according to which ketamine effectively eliminates suicidal thoughts not only in depression, but also in other psychiatric diseases. According to the researcher, this is a very important discovery, because not all suicides are associated with depression. Post-traumatic stress disorder (PTSD), borderline personality disorder, alcohol and drug abuse can also lead to suicide.
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They do now
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While researchers continue to study ketamine, practices such as Dr. Lapidus have already begun to treat patients. In the list Ketamine Advocacy Network today including 17 katarinovich clinics throughout the United States. Anesthesiologist Enrique Abreu (Enrique Abreu) runs the Ketamine clinic Portland in Oregon. It works together with a specialist in psychiatry Dr. Marilyn Sears (Sears Marilyn), co-founder of the clinic. They treat patients with persistent depression with intravenous ketamine administration. Many of their patients went to the clinic themselves, without a psychiatrist. "These people suffer, and they find us on the Internet," explains Dr. Abreu, who has already cured more than 30 patients from depression over 15 months of clinic operation. He says he doesn't have psychiatric practice behind him, but he's been using ketamine for anesthesia for 15 years, so he knows pretty much everything about this drug. In fact, many operators of ketamine clinics are former anesthesiologists. "This is a strange gray area of knowledge. Who can help these people and do it safely?"says Dr. Abreu. Of course, before you begin to help patients with depression, Dr. Abreu consults with a psychiatrist and therapist. Treatment consists of 6 infusions over 12 days. Each procedure lasts about 45 minutes. Side effects usually include temporary disturbances of consciousness and vision. Patients are closely monitored and then transported home by a pre-ordered car. They are not recommended to operate the machine and dangerous mechanisms for 24 hours. Abreu says that the side effects of ketamine " take place shortly after infusion, and patients do not experience hallucinations." According to the head of the clinic, about ¾ patients aged 15 to 55 years are treated with ketamine. Older patients respond worse to such treatment. 6 initial infusions at the clinic ketaminebuy cost 3 $ 800. Positive effects of ketamine are usually 3-5 weeks after treatment, sometimes up to 12 weeks. Patients who return after this course usually need a single procedure ($600). Since the FDA has not approved the treatment of ketamine depression, insurance will not cover it. Dr. Lapidus said that his clinic in new York uses ketamine mainly in the form of nasal spray – this method he and his colleagues from the School of medicine, Icahn at Mount Sinai is considered the most effective. They published data from their study on the subject in April 2014. Dr. Manevitz, who also uses ketamine in his practice, says that the short-term effect of the drug is obvious, but the long-term effectiveness of ketamine in depression is not yet known. Maintaining the original effect he calls the biggest ketamine problem. This issue requires further research.
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One of the aspects that I love most about this network called Steemit, is the fact that it deals with publishing quality articles in different areas, in my personal case as a University Professor and researcher of Ingniería I love science and technology, additionally Due to my passion and my high human sensibility, I have been working in social areas such as motivation, leadership, marketing, coaching. By integrating all these activities, I am allowed to write a Motivation book, which I have published in Amazon Here you can find it , also in the portal Authors editors Here you can find it of Colombia, as well as some Libraries of the Northern area of the state Anzoátegui Venezuela
My Book is writing in spanish
Excellent publication
My congratulations
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gracias.
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that is medicine forr injection, maybe that we can said vial or drug kentamine.
this post is very useful so as not in one use for the teenagers now @justtrymen90
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Its not a drug to be played around with that is for sure. Also if you comment on a post you should upvote it in some way.
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was upvote, can you help me please @justtryme90
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excellent post D:
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@justtrymen90. Post very good. Is Ketamine safe for pregnant and lactating women?
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No
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Thank you @justtrymen90. I'm very happy to information. Because I'm Hemodialysis Nurses
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Ketamine is very good medicare @justtryme90
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I really appreciate the work that sciencie is doing for us people that suffer from a condition that causes depression. I have never tried one of those medicines, but I'm sure they'll finally discover something that is worth to take without side effects. Sincerely, Ralk98.
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Very good
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I'm excited there's moire research being done on these types of compounds. I wonder if there's a similarity in how psilocybin works? In my experience it can also help depression for months with one dose.
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The active form of psilocybin in the body, psilocin is an agonist of serotonin receptors (mostly because it is chemically very similar to serotonin). So the mechanism by which Psilocybin works would be more similar to a standard SSRI anti depressant as it mimics serotonin binding (and those just increase serotonin concentrations).
This is very different from what Ketamine is doing.
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SSRI drugs don't relieve depression in one session with one dose though, psilocybin seems to be able to, it certainly has in my experience. There must be more to it.
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I was more referring to the receptor involved then the kinetics of the effect. There is definitely more to it, then the simplified statement I made above :)
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Wow!!Gran publicación.
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Can the drug be good for ulcer patient
I'm asking because I am one
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Ulcer would not be the use case for this.
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Nice post
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Wow this a good post😎
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If you're interested in the subject then check the link below, it's possibly the most major breakthrough in researching schizophrenia ever. Researchers found abnormal vessels that undermine the structure that delivers blood into the brain could play a significant role in the development of schizophrenia. This is major because now researchers can completely switch their focus and physically treat the vessels in the brain instead of targeting the symptoms.
https://www.tcd.ie/news_events/articles/scientists-identify-new-mechanism-for-the-development-of-schizophrenia/8251
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Nice post boss; about the tag steemSTEM.
Nice post boss; about the tag steemSTEM.
I posted this article on the steemstem tag but wasn't even reviewed on the stem platform, thought it wise if u as an enzymologist to check it out yourself, thanks.
https://steemit.com/biochemistry/@dazzy/why-enzymes-are-important
@dazzy
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super post
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| also has the convenient effect of causing memory loss.
Hey just wanted to know if the loss is of permanent or temporary type.
And did you say we can get high off of it ;).
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Permanent
If you want to die, sure.
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Let's hope that we get to extract its beneficial properties while minimizing the adverse effects.
The Burden of Existence! haha.
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That will hopefully be the focus of subsequent research. :)
Large, but the alternative is worse. ;)
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Good post
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Great information. 👏
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Thanks........Thanks............semoga sukses
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Hi justtryme90
We could all use less depression. Thanks for sharing with me.
Also Thanks for looking at my photo and upvoting it.
Have a nice day.
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thank you @justtryme90 very useful postings for all
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Oh wow very interesting information thank you for sharing
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The drug ketamine is good but the fact that it can lead to memory loss is not a good idea.
I think professional surgeon will use this only under severe cases. As it will not look really good for a patient who is mentally fine before undergoing a surgery to wake up and start having memory malfunctioning. I believer the researcher will still be working in how to avoid patient from having memory loss after using it.
I might have to keep checking in case there is any new update on the drug.
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It's frequently used. You don't want people remembering surgery. People don't want to remember it either. Anesthetics are meant to keep you out of it after all.
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Good to know anesthetics will take people out of trance, i was about to ask if the drug might such individual loose memory before the event i mean before surgery
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