Digital technology will NEVER be able to replicate some processes in the natural world that are typically based on fractals. These supercomputers are also extremely limited in areas where chaos theory governs the system being analyzed (weather is a good example). In analyzing those types of systems there is an upper limit on the probability of correctly modeling the system in question and the more chaotic the system, the lower that boundary is.

Another area where mainstream science is way off base is assuming a digital system can replicate an organic one - i.e. modeling the human brain. This will never happen simply because the underlying mechanisms are too different. The human brain is like a holographic analogue computer - which is completely different compared to how a binary computer system works.