Yeast Cell Factories Thematic Issue
What does yeast have to do with jet fuel, perfume, and antibodies? A lot! Engineered yeast can produce all these, and more, using renewable feedstocks in fermentation.
With cheaper and faster engineering now available, scientists are no longer limited to guessing which genetic modifications will improve cellular performance, but can tap into vast amounts of system-level data instead. Hence, the emergence of novel commercial processes that use genetically engineered yeasts as cell factories to produce a range of materials including biofuels, isoprenoids, aromatics, and recombinant proteins.
Read a series of MiniReviews below from leaders in the field which explore recent advances in metabolic engineering and the synthetic biology of yeast, curated by Guest Editors Irina Borodina and Zongbao Kent Zhao.
Transporter engineering in biomass utilization by yeast imageTransporter engineering in biomass utilization by yeast
Kiyotaka Y. Hara, Jyumpei Kobayashi, Ryosuke Yamada, Daisuke Sasaki, Yuki Kuriya, Yoko Hirono-Hara, Jun Ishii, Michihiro Araki, Akihiko Kondo
DOI: 10.1093/femsyr/fox061
Engineering Saccharomyces cerevisiae for High-Level Synthesis of Fatty Acids and Derived Products
Ruben Fernandez-Moya, Nancy A. Da Silva
DOI: 10.1093/femsyr/fox071
Genome-scale modeling of yeast imageGenome-scale modeling of yeast: chronology, applications and critical perspectives
Helder Lopes, Isabel Rocha
DOI: 10.1093/femsyr/fox050
Pathway engineering for the production of heterologous aromatic chemicals and their derivatives in Saccharomyces cerevisiae: bioconversion from glucosePathway engineering for the production of heterologous aromatic chemicals and their derivatives in Saccharomyces cerevisiae: bioconversion from glucose
Manuela Gottardi, Mara Reifenrath, Eckhard Boles, Joanna Tripp
DOI: 10.1093/femsyr/fox035