Author: @madridbg, via Power Point 2010, using public domain images. Colin Behrens
Greetings and welcome dear readers of this prestigious platform, especially to all those users who make daily life in the @projecthope community, the purpose of this publication is to make a conceptual approach about the presence of female infertility as a process associated with imbalances at the genome level.
In this sense, to understand the functioning of this biomedical process, we will rely on the research that has been carried out by the Biomedical Research Institute of Salamanca, where they have been able to identify the coercion of the RAD51D gene on female fertility, as well as genomic stability.
Thus, small structural modifications at the level of this gene produce considerable alterations in chromosomal segregation, generating various diseases in human health.
Fig. 2. Representation of the RAD51 protein. Author: Conway
Among these diseases, it is necessary to highlight those related to infertility, as well as the appearance of malformations at the chromosome level, specifically on somatic cells, a process that has been demonstrated through in vitro evaluations. in vitro on mice, highlighting serious conditions at the level of the pituitary of these species, since specific tumors have been located in these areas and are associated with the prevalence of the RAB51D gene.
In this sense, in this changing world and where synthetic products have invaded our society, the degree of infertility is constantly growing and it is estimated that more than 15% of young couples in normally reproductive age, are classified as infertile, highlighting these negative effects the presence of the previously studied gene, as well as the presence of primary ovarian capacity that gradually affects females under 40 years of age.
Thus, the techniques associated with massive sequencing at the genomic level have allowed us to have a better perspective on the evolution and presence of mutations in the genes involved in family development and offspring problems. and inheritance.
Therefore, it is necessary to understand that some of the problems begin with poor protein coding on the basis of meiosis, understand this as the cell division in which, from diploid cells, they obtain haploid cells, so that during this process the purpose is to generate haploid-type gametes, that is, with the presence of a set of chromosomes, this mechanism becoming the fundamental basis of sexual reproduction and genetic recombination.
Fig. 3. Representation of the process of meiosis. Author: Aibdescalzo
Consequently, it has been possible to determine that RAD51-type proteins are essential in the first phases of meiosis and when they are altered, failures or problems associated with female infertility occur.
Consequently, the study being carried out has allowed a sequencing of the protein-type coding genome associated with the RAD51B gene, which has replicated in mice, which has allowed corroborating the hypothesis that when the gene undergoes mutations, it produces Truncated RAD51-type proteins, at one end, affecting the normal functioning of meiosis as a mechanism of cell division, likewise, the condition of this gene causes a defective protein overaccumulation so that it affects on the presence of can cells
The design of the portal was made by @madridbg, using public domain images
Uploaded image of the Proyecto.hope community
OF INTEREST
Grateful with the community @project.hope and with all the management team of the same one that they motivate us to continue working in a mutual and balanced growth.
Hi @madridbg
These numbers are truly alarming and can cause a lot of genetic mutations affecting the evolution of human civilization in not a very good way.
Hope govt. as well as individuals see the warning signs and act before it becomes too late.
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